Hair Follicular Cell/Organ Culture in Tissue Engineering and Regenerative Medicine

October 2009 in “ Biochemical Engineering Journal ”

Bo-Young Yoo, Youn-Ho Shin, Hee-Hoon Yoon, Young-Kwon Seo, Jung-Keug Park

hair follicle hair follicle cell culture regenerative medicine growth factors minoxidil cyclosporin A in vitro hair follicle cell culture organ culture models 3D hair growth model anagen phase hair multiplication technology mesenchymal stem cells alopecia stem cell therapy Rogaine stem cells

TLDR Stem cell therapy is a promising approach for hair regrowth despite potential side effects.

The document from 2010 reviews the structure and function of hair follicles, the challenges of traditional hair loss treatments, and the potential of in vitro hair follicle cell culture for regenerative medicine. It details the isolation and role of various hair follicle cells, including their response to growth factors and drugs like minoxidil and cyclosporin A. The paper highlights the development of in vitro and organ culture models to study hair growth and test hair-related drugs, including a 3D hair growth model that showed improved hair length and maintenance of the anagen phase. It also discusses advancements in hair multiplication technology, with a 70% success rate in male hair regrowth reported by Intercytex, and the potential of mesenchymal stem cells for treating alopecia. The document concludes that stem cell therapy holds great promise for hair follicle research, despite concerns about side effects.

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Research cited in this study

46 / 46 results

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Hair follicle stem cells can generate all hair cell types, skin, and sebaceous glands.

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Human hair growth can be influenced by certain growth factors and has specific metabolic needs.

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Human dermal fibroblasts and hair papilla cells help outer root sheath cells grow and develop properly.

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Dermal papillae are crucial for hair growth and follicle development.

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Human hair follicles can grow in a lab for at least 9 days without serum, keeping their natural characteristics.

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Human hair follicles can grow in a lab setting.

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Hair Physiology: Hair Growth, Alopecia, Scalp Treatment, Etc.