Hair Follicular Cell/Organ Culture in Tissue Engineering and Regenerative Medicine

October 2009 in “ Biochemical Engineering Journal ”

Bo-Young Yoo, Youn-Ho Shin, Hee-Hoon Yoon, Young-Kwon Seo, Jung-Keug Park

hair follicle hair follicle cell culture regenerative medicine growth factors minoxidil cyclosporin A in vitro hair follicle cell culture organ culture models 3D hair growth model anagen phase hair multiplication technology mesenchymal stem cells alopecia stem cell therapy Rogaine stem cells

TLDR Stem cell therapy is a promising approach for hair regrowth despite potential side effects.

The document from 2010 reviews the structure and function of hair follicles, the challenges of traditional hair loss treatments, and the potential of in vitro hair follicle cell culture for regenerative medicine. It details the isolation and role of various hair follicle cells, including their response to growth factors and drugs like minoxidil and cyclosporin A. The paper highlights the development of in vitro and organ culture models to study hair growth and test hair-related drugs, including a 3D hair growth model that showed improved hair length and maintenance of the anagen phase. It also discusses advancements in hair multiplication technology, with a 70% success rate in male hair regrowth reported by Intercytex, and the potential of mesenchymal stem cells for treating alopecia. The document concludes that stem cell therapy holds great promise for hair follicle research, despite concerns about side effects.

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Research cited in this study

26 / 26 results

research A Cell-Based System for Screening Hair Growth-Promoting Agents

39 citations, March 2009 in “Archives of Dermatological Research”

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research A Human Folliculoid Microsphere Assay for Exploring Epithelial-Mesenchymal Interactions in the Human Hair Follicle

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HFMs can help study hair growth and test potential hair growth drugs.

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43 citations, August 2008 in “Regenerative Medicine”

Scientists created early-stage hairs from mouse cells that grew into normal, pigmented hair when implanted into other mice.

research Microencapsulated Human Hair Dermal Papilla Cells: A Substitute for Dermal Papilla?

25 citations, April 2008 in “Archives of Dermatological Research”

Encapsulated human hair cells can substitute for natural hair cells to grow hair.

research Induction of Synapse Associated Protein 102 Expression in Cyclosporin A-Stimulated Hair Growth

5 citations, February 2008 in “Experimental Dermatology”

Cyclosporin A promotes hair growth in mice and increases a protein linked to hair growth, but it may not work the same way in humans.

Establishment of SV40T-Transformed Human Dermal Papilla Cells and Identification of Dihydrotestosterone-Regulated Genes by cDNA Microarray

research Establishment of SV40T-Transformed Human Dermal Papilla Cells and Identification of Dihydrotestosterone-Regulated Genes by cDNA Microarray

13 citations, June 2007 in “Journal of Dermatological Science”

Researchers created a cell line to study hair growth and found specific genes affected by dihydrotestosterone.

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96 citations, April 2007 in “Journal of Investigative Dermatology”

Grafted rodent and human cells can regenerate hair follicles, but efficiency decreases with age.

research The Additive Effects of Minoxidil and Retinol on Human Hair Growth In Vitro

32 citations, January 2007 in “Biological & Pharmaceutical Bulletin”

Minoxidil and retinol together help hair grow.

research Induction of Versican by Ascorbic Acid 2-Phosphate in Dermal Papilla Cells

22 citations, April 2006 in “Journal of Dermatological Science”

Vitamin C derivative increases versican in cells, potentially aiding hair growth.

research The Hair Growth Promoting Effect of Ascorbic Acid 2-Phosphate, a Long-Acting Vitamin C Derivative

33 citations, January 2006 in “Journal of Dermatological Science”

A long-acting Vitamin C derivative helps hair grow by stimulating cells and increasing growth factors.

research Organogenesis From Dissociated Cells: Generation of Mature Cycling Hair Follicles From Skin-Derived Cells

205 citations, April 2005 in “Journal of Investigative Dermatology”

Scientists have found a way to create hair follicles from skin cells of newborn mice, which can grow and cycle naturally when injected into adult mouse skin.

research Molecular Principles of Hair Follicle Induction and Morphogenesis

479 citations, January 2005 in “BioEssays”

Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.

research Cultured Human and Rat Tooth Papilla Cells Induce Hair Follicle Regeneration and Fiber Growth

48 citations, December 2004 in “Differentiation”

Tooth papilla cells can help regenerate hair follicles and grow hair.

research Effect of Minoxidil on Proliferation and Apoptosis in Dermal Papilla Cells of Human Hair Follicle

149 citations, April 2004 in “Journal of Dermatological Science”

Minoxidil boosts hair growth by increasing cell production and survival.

Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla

research Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla

208 citations, December 2003 in “Journal of Investigative Dermatology”

Certain cells from hair follicles can create new hair and contribute to hair growth when implanted in mice.

research Hair Follicle Stem Cells: Insights from the 2003 Workshop

142 citations, June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

Hair follicle stem cells can generate all hair cell types, skin, and sebaceous glands.

research Identification of Androgen-Regulated Genes in SV40-Transformed Human Hair Dermal Papilla Cells

12 citations, May 2003 in “Journal of dermatological science”

Hsc70 protein may influence hair growth by responding to androgens.

research The Hair Growth Promoting Effect of Sophora Flavescens Extract and Its Molecular Regulation

75 citations, October 2002 in “Journal of Dermatological Science”

Sophora flavescens extract may help hair grow by affecting growth factors and blocking a hair-related enzyme.

research Simple and Rapid Method to Isolate and Culture Follicular Papillae from Human Scalp Hair Follicles

78 citations, August 2002 in “Experimental Dermatology”

Researchers developed a quick and easy way to get and grow cells from the base of human hair follicles.

research Current and Potential Agents for the Treatment of Alopecia Areata

41 citations, February 2001 in “Current pharmaceutical design”

Current and future treatments for alopecia areata focus on immunosuppression, immunomodulation, and protecting hair follicles.

research Differences in Hair Follicle Dermal Papilla Volume Are Due to Extracellular Matrix Volume and Cell Number: Implications for the Control of Hair Follicle Size and Androgen Responses

231 citations, December 1999 in “Journal of Investigative Dermatology”

Hair follicle size is mainly influenced by the number of cells and extracellular matrix volume, with cell number having a larger impact.

Growth Factors and Cytokines in Hair Follicle Development and Cycling: Recent Insights from Animal Models and the Potentials for Clinical Therapy

research Growth Factors and Cytokines in Hair Follicle Development and Cycling: Recent Insights from Animal Models and the Potentials for Clinical Therapy

100 citations, November 1996 in “Molecular Medicine Today”

Growth factors and cytokines are important for hair growth and could potentially treat hair loss, but more research is needed to overcome challenges before they can be used in treatments.

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114 citations, October 1996 in “Dermatologic clinics”

Hair loss is mainly caused by hormones, autoimmune issues, and chemotherapy, and needs more research for treatments.

research Hair Matrix Germinative Epidermal Cells Confer Follicle-Inducing Capabilities on Dermal Sheath and High Passage Papilla Cells

61 citations, October 1996 in “Development”

Hair growth can be stimulated by combining certain skin cells, which can rejuvenate old cells and cause them to specialize in hair follicle creation.

research Effects of Epidermal Growth Factor on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles

94 citations, February 1994 in “The journal of investigative dermatology/Journal of investigative dermatology”

EGF makes hair follicles grow longer but stops hair production.

research Hair Growth In Vitro From Histocultured Skin

25 citations, August 1992 in “In vitro cellular & developmental biology”

The new system can grow hair in the lab and test hair growth treatments.

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research Hair Physiology: Hair Growth, Alopecia, Scalp Treatment, Etc.

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The document concludes that new treatments for hair loss may involve a combination of cosmetics, clinical methods, and genetic approaches.

research Do Hair Bulb Melanocytes Undergo Apoptosis During Hair Follicle Regression (Catagen)?

130 citations, December 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

Hair follicle melanocytes die during hair regression.