Hair Follicular Cell/Organ Culture in Tissue Engineering and Regenerative Medicine

October 2009 in “ Biochemical Engineering Journal ”

Bo-Young Yoo, Youn-Ho Shin, Hee-Hoon Yoon, Young-Kwon Seo, Jung-Keug Park

hair follicle hair follicle cell culture regenerative medicine growth factors minoxidil cyclosporin A in vitro hair follicle cell culture organ culture models 3D hair growth model anagen phase hair multiplication technology mesenchymal stem cells alopecia stem cell therapy Rogaine stem cells

TLDR Stem cell therapy is a promising approach for hair regrowth despite potential side effects.

The document from 2010 reviews the structure and function of hair follicles, the challenges of traditional hair loss treatments, and the potential of in vitro hair follicle cell culture for regenerative medicine. It details the isolation and role of various hair follicle cells, including their response to growth factors and drugs like minoxidil and cyclosporin A. The paper highlights the development of in vitro and organ culture models to study hair growth and test hair-related drugs, including a 3D hair growth model that showed improved hair length and maintenance of the anagen phase. It also discusses advancements in hair multiplication technology, with a 70% success rate in male hair regrowth reported by Intercytex, and the potential of mesenchymal stem cells for treating alopecia. The document concludes that stem cell therapy holds great promise for hair follicle research, despite concerns about side effects.

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Research cited in this study

26 / 26 results

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43 citations , August 2008 in “Regenerative Medicine”

Scientists created early-stage hairs from mouse cells that grew into normal, pigmented hair when implanted into other mice.

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25 citations , April 2008 in “Archives of Dermatological Research”

Encapsulated human hair cells can substitute for natural hair cells to grow hair.

research Induction of Synapse Associated Protein 102 Expression in Cyclosporin A-Stimulated Hair Growth

5 citations , February 2008 in “Experimental Dermatology”

Cyclosporin A promotes hair growth in mice and increases a protein linked to hair growth, but it may not work the same way in humans.

Establishment of SV40T-Transformed Human Dermal Papilla Cells and Identification of Dihydrotestosterone-Regulated Genes by cDNA Microarray

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Researchers created a cell line to study hair growth and found specific genes affected by dihydrotestosterone.

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96 citations , April 2007 in “Journal of Investigative Dermatology”

Grafted rodent and human cells can regenerate hair follicles, but efficiency decreases with age.

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32 citations , January 2007 in “Biological & Pharmaceutical Bulletin”

Minoxidil and retinol together help hair grow.

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22 citations , April 2006 in “Journal of Dermatological Science”

Vitamin C derivative increases versican in cells, potentially aiding hair growth.

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33 citations , January 2006 in “Journal of Dermatological Science”

A long-acting Vitamin C derivative helps hair grow by stimulating cells and increasing growth factors.

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205 citations , April 2005 in “Journal of Investigative Dermatology”

Scientists have found a way to create hair follicles from skin cells of newborn mice, which can grow and cycle naturally when injected into adult mouse skin.

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479 citations , January 2005 in “BioEssays”

Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.

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48 citations , December 2004 in “Differentiation”

Tooth papilla cells can help regenerate hair follicles and grow hair.

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149 citations , April 2004 in “Journal of Dermatological Science”

Minoxidil boosts hair growth by increasing cell production and survival.

Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla

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208 citations , December 2003 in “Journal of Investigative Dermatology”

Certain cells from hair follicles can create new hair and contribute to hair growth when implanted in mice.

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Hair follicle stem cells can generate all hair cell types, skin, and sebaceous glands.

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12 citations , May 2003 in “Journal of dermatological science”

Hsc70 protein may influence hair growth by responding to androgens.

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75 citations , October 2002 in “Journal of Dermatological Science”

Sophora flavescens extract may help hair grow by affecting growth factors and blocking a hair-related enzyme.

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78 citations , August 2002 in “Experimental Dermatology”

Researchers developed a quick and easy way to get and grow cells from the base of human hair follicles.

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41 citations , February 2001 in “Current pharmaceutical design”

Current and future treatments for alopecia areata focus on immunosuppression, immunomodulation, and protecting hair follicles.

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Hair follicle size is mainly influenced by the number of cells and extracellular matrix volume, with cell number having a larger impact.

Growth Factors and Cytokines in Hair Follicle Development and Cycling: Recent Insights from Animal Models and the Potentials for Clinical Therapy

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100 citations , November 1996 in “Molecular Medicine Today”

Growth factors and cytokines are important for hair growth and could potentially treat hair loss, but more research is needed to overcome challenges before they can be used in treatments.

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Hair loss is mainly caused by hormones, autoimmune issues, and chemotherapy, and needs more research for treatments.

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61 citations , October 1996 in “Development”

Hair growth can be stimulated by combining certain skin cells, which can rejuvenate old cells and cause them to specialize in hair follicle creation.

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94 citations , February 1994 in “The journal of investigative dermatology/Journal of investigative dermatology”

EGF makes hair follicles grow longer but stops hair production.

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25 citations , August 1992 in “In vitro cellular & developmental biology”

The new system can grow hair in the lab and test hair growth treatments.

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Hair follicle melanocytes die during hair regression.