Effect of Mesenchymal Cells on Human Hair Growth and Death

March 2008 in “ Korean Journal of Chemical Engineering ”

Bo-Young Yoo, Young‐Kwon Seo, Hee‐Hoon Yoon, Youn-Ho Shin, Kye‐Yong Song, Jung‐Keug Park

mesenchymal cells hair growth gel-type dermal equivalent dermal papilla cells dermal sheath cells hair follicles anagen phase paracrine factors in vitro models scalp tissue

TLDR Mesenchymal cells can significantly boost human hair growth and longevity.

The study investigated the effects of mesenchymal cells on human hair growth using a gel-type dermal equivalent (DE) containing dermal papilla cells (DPCs) or dermal sheath cells (DSCs) isolated from human hair bulbs. Hair follicles were organ-cultured on DE, and it was found that DE containing DSCs led to a significant increase in hair length and long-term viability when cultured at the air-liquid interface. This method maintained the growth phase (anagen) longer than submerged cultures, likely due to improved oxygen supply and paracrine factors from hair origin cells. The study highlighted the potential of using in vitro models to mimic human scalp tissue for hair growth research.

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