61 citations
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October 1996 in “Development” Hair growth can be stimulated by combining certain skin cells, which can rejuvenate old cells and cause them to specialize in hair follicle creation.
37 citations
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January 2022 in “Frontiers in Genetics” The study utilized single-cell RNA sequencing to analyze 72,048 cells from human skin biopsies of various ages, focusing on the dermal sheath (DS) cells, which are crucial for skin homeostasis and include hair follicle dermal stem cells. It was found that DS cells with stem cell characteristics were lost with aging. Key regulators of DS stem cell characteristics were identified as HES1, COL11A1, MYL4, and CTNNB1. Additionally, the DS secreted protein Activin A was shown to have paracrine effects, enhancing keratinocyte and dermal fibroblast proliferation, epidermal thickness, and pro-collagen production, contributing to a juvenile skin phenotype. This research provided a comprehensive understanding of the human DS at the single-cell level, highlighting its decline with age and its role in maintaining youthful skin.
16 citations
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July 2019 in “Biochemical and Biophysical Research Communications” CD36-expressing dermal sheath cells help form blood vessels in hair follicles, aiding hair growth.
10 citations
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February 2016 in “Journal of Dermatological Science” Skin sheath cells help in hair growth and renewal after birth.
6 citations
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September 2009 in “European journal of histochemistry” CD90 is present on specific cells in dog hair follicles.