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    Glossary Dermal Sheath Cells

    specialized cells surrounding hair follicle bases, aiding growth

    Dermal Sheath Cells are specialized cells that surround the base of hair follicles. They play a crucial role in hair growth and regeneration by providing structural support and signaling molecules that influence the behavior of other cells within the hair follicle. These cells are essential for maintaining the health and function of hair follicles, making them a key focus in research on hair loss and treatments for conditions like alopecia.

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    1. Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type Developmental Cell · 2014 · 184 citations
    2. Hair matrix germinative epidermal cells confer follicle-inducing capabilities on dermal sheath and high passage papilla cells Development · 1996 · 61 citations
    3. Single-Cell RNA Profiling of Human Skin Reveals Age-Related Loss of Dermal Sheath Cells and Their Contribution to a Juvenile Phenotype Frontiers in Genetics · 2022 · 37 citations
    4. Human hair follicle dermal papilla cell, dermal sheath cell and interstitial dermal fibroblast characteristics. PubMed · 1996 · 36 citations
    5. Characterization of human dermal sheath cells reveals CD36-expressing perivascular cells associated with capillary blood vessel formation in hair follicles Biochemical and Biophysical Research Communications · 2019 · 16 citations
    6. Expression of mesenchymal stem cell marker CD90 on dermal sheath cells of the anagen hair follicle in canine species European Journal of Histochemistry · 2009 · 15 citations
    7. Dermal sheath cells contribute to postnatal hair follicle growth and cycling Journal of Dermatological Science · 2016 · 10 citations
    8. Expression of mesenchymal stem cell marker CD90 on dermal sheath cells of the anagen hair follicle in canine species European journal of histochemistry · 2009 · 6 citations
    9. Establishment of dermal sheath cell line from Cashmere goat and characterizing cytokeratin 13 as its novel biomarker Biotechnology Letters · 2018 · 2 citations
    10. Single-Cell Proteomics Uncovers Dual Traits of Dermal Sheath Cells in Wound Repair Advances in Wound Care · 2025 · 1 citations
    11. Exploring the Role of Dermal Sheath Cells in Wound Healing and Fibrosis Preprints.org · 2024 · 1 citations
    12. The Growth of Human Dermal Papilla Cells and Dermal Sheath Cells in Vitro Chinese Journal of Dermatology · 2001
    13. Growth kinetics of cultured dermal papilla cells and dermal sheath cells from human hair follicles Acta Academiae Medicine Militaris Tertiae · 2000
    14. Dermal Sheath Cells and Hair Follicle Regeneration Stem cell biology and regenerative medicine · 2022
    15. Combatting ageing in dermal papilla cells and promoting hair follicle regeneration using exosomes from human hair follicle dermal sheath cup cells Experimental Dermatology · 2023
    16. Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla Journal of Investigative Dermatology · 2003 · 208 citations
    17. The chemotactic effect of a dermal papilla cell-derived factor on outer root sheath cells Journal of Dermatological Science · 2001 · 47 citations
    18. Autologous cell–based therapy for male and female pattern hair loss using dermal sheath cup cells: A randomized placebo-controlled double-blinded dose-finding clinical study Journal of The American Academy of Dermatology · 2020 · 22 citations
    19. Human Hair Outer Root Sheath Cells and Platelet-Lysis Exosomes Promote Hair Inductivity of Dermal Papilla Cell Tissue Engineering and Regenerative Medicine · 2020 · 9 citations
    20. Changes in the Expression of Smooth Muscle Cell–Related Genes in Human Dermal Sheath Cup Cells Associated with the Treatment Outcome of Autologous Cell–Based Therapy for Male and Female Pattern Hair Loss International Journal of Molecular Sciences · 2022 · 2 citations
    21. High migratory activity of dermal sheath cup cells associated with the clinical efficacy of autologous cell-based therapy for pattern hair loss Journal of Dermatological Science · 2023
    22. Efficacy of autologous dermal sheath cup cell transplantation in male and female pattern hair loss: A Single‐Arm, Multi‐Center, phase III equivalent clinical study The Journal of Dermatology · 2023
    23. 602 Efficacy of autologous cell-based therapy for male and female pattern hair loss using dermal sheath cup cells: A single arm, multi-center, confirmatory clinical study Journal of Investigative Dermatology · 2023
    24. Effect of minoxidil sulfate and pinacidil on single potassium channel current in cultured human outer root sheath cells and dermal papilla cells Journal of Dermatological Science · 1994 · 16 citations
    25. Interferon β Secreted from Human Hair Dermal Papilla Cells Inhibits the Growth of Outer Root Sheath Cells Cultured in Vitro Biochemical and biophysical research communications · 2002 · 13 citations
    26. 18-β-Glycyrrhetinic Acid Promotes Hair Growth by Stimulating the Proliferation of Dermal Papilla Cells and Outer Root Sheath Cells, and Extends the Anagen Phase by Inhibiting 5α-Reductase Biological and Pharmaceutical Bulletin · 2024
    27. Faculty Opinions recommendation of Dermal sheath contraction powers stem cell niche relocation during hair cycle regression. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2020
    28. Sex hormones and antiandrogens influence in vitro growth of dermal papilla cells and outer root sheath keratinocytes of human hair follicles 1993 · 9 citations
    29. Immunophenotypical analyses of myofibroblasts in rat excisional wound healing: possible transdifferentiation of blood vessel pericytes and perifollicular dermal sheath cells into myofibroblasts. PubMed · 2012 · 26 citations
    30. Human Scalp Dermal Papilla and Fibrous Sheath Cells have a different expression profile of Matrix Metalloproteinases in vitro when compared to Scalp Dermal Fibroblasts Archives of Dermatological Research · 2005 · 9 citations