Characterization of Human Dermal Sheath Cells Reveals CD36-Expressing Perivascular Cells Associated with Capillary Blood Vessel Formation in Hair Follicles

July 2019 in “ Biochemical and Biophysical Research Communications ”

Yuzo Yoshida, Tsutomu Soma, Jiro Kishimoto

dermal sheath cells CD36 perivascular cells angiogenesis anagen phase endothelial cells hair follicles hair cycling vascular-related genes dermal papilla cells dermal fibroblasts blood vessel formation hair growth phase blood capillaries hair follicle regeneration

TLDR CD36-expressing dermal sheath cells help form blood vessels in hair follicles, aiding hair growth.

The study characterized human dermal sheath (DS) cells, revealing their association with blood vessel formation in hair follicles. It was found that CD36-expressing DS cells were present in perivascular areas and may play a role in angiogenesis during the early anagen phase of hair growth. These cells were shown to help endothelial cells proliferate, suggesting their involvement in modulating blood capillaries in hair follicles in association with hair cycling. The research highlighted the potential of DS cells in hair follicle regeneration and their significant expression of vascular-related genes compared to dermal papilla (DP) cells and dermal fibroblasts.

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