Characterization of Human Dermal Sheath Cells Reveals CD36-Expressing Perivascular Cells Associated with Capillary Blood Vessel Formation in Hair Follicles

July 2019 in “ Biochemical and Biophysical Research Communications ”

Yuzo Yoshida, Tsutomu Soma, Jiro Kishimoto

dermal sheath cells CD36 perivascular cells angiogenesis anagen phase endothelial cells hair follicles hair cycling vascular-related genes dermal papilla cells dermal fibroblasts blood vessel formation hair growth phase blood capillaries hair follicle regeneration

TLDR CD36-expressing dermal sheath cells help form blood vessels in hair follicles, aiding hair growth.

The study characterized human dermal sheath (DS) cells, revealing their association with blood vessel formation in hair follicles. It was found that CD36-expressing DS cells were present in perivascular areas and may play a role in angiogenesis during the early anagen phase of hair growth. These cells were shown to help endothelial cells proliferate, suggesting their involvement in modulating blood capillaries in hair follicles in association with hair cycling. The research highlighted the potential of DS cells in hair follicle regeneration and their significant expression of vascular-related genes compared to dermal papilla (DP) cells and dermal fibroblasts.

View this study on sciencedirect.com →

Discuss this study in the Community →

Research cited in this study

6 / 6 results

research A Guide to Studying Human Hair Follicle Cycling In Vivo

212 citations, September 2015 in “Journal of Investigative Dermatology”

The document provides a method to classify human hair growth stages using a model with human scalp on mice, aiming to standardize hair research.

research Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type

184 citations, November 2014 in “Developmental Cell”

Hair follicle dermal stem cells are key for regenerating parts of the hair follicle and determining hair type.

research The Mesenchymal Component of Hair Follicle Neogenesis: Background, Methods, and Molecular Characterization

131 citations, July 2009 in “Experimental Dermatology”

The document concludes that specific cells are essential for hair growth and more research is needed to understand how to maintain their hair-inducing properties.

Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla

research Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla

208 citations, December 2003 in “Journal of Investigative Dermatology”

Certain cells from hair follicles can create new hair and contribute to hair growth when implanted in mice.

research Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis

520 citations, February 2001 in “Journal of Clinical Investigation”

VEGF helps hair grow and determines follicle size by increasing blood vessel growth.

research The Upper Dermal Sheath Has Potential to Regenerate Hair in Rat Follicular Epidermis

31 citations, September 1996 in “Differentiation”

The upper dermal sheath can regenerate hair in rats.

Related Community Posts Join

6 / 1000+ results

community Shiseido filed for this patent in May 2019. Let's get some big brain discussion on this.

6 upvotes 5 years ago

The conversation discusses a patent filed by Shiseido for cloning Dermal Papilla (DP) cells to treat hair loss. The method involves using viral vectors to maintain the cells' growth-inducing properties, differing from Replicel's approach with Dermal Sheath Cup (DSC) cells.

community Scientists in Japan develop a new technique to reverse balding by transplanting a special kind of hair follicle cell into a patient's scalp

in Treatment 184 upvotes 5 years ago

A new technique developed by scientists in Japan to reverse balding using hair follicle cell transplants, and the discussion around the effectiveness of this approach compared to other treatments such as Minoxidil, finasteride, RU58841, Replicel, and Hairclone.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 10 months ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community A Different Take on Curing MBP

16 upvotes 6 years ago

Addressing hair loss by focusing on posture, blood flow, and craniofacial development. Methods include improving posture, cardiovascular activity, scalp massages, healthy diet, meditation, using minoxidil, and addressing craniofacial issues.

community This serum outperformed Minoxidil in a recent study. Please debunk

23 upvotes 5 years ago

A topical solution called "Multi-Peptide Serum for Hair Density" by The Ordinary Company, which contains several ingredients that are used in alternatives to Minoxidil and was found to have better results than 5% Minoxidil in a study. People who have tried it shared their experiences with the serum as well.

community Minoxidil Response Bottlenecks: Why Sulfation and Transport Matter (And Where Tretinoin Fits In)

in Research 461 upvotes 2 months ago

Minoxidil's effectiveness is limited by the need for sulfation and proper transport to hair follicles, with tretinoin potentially enhancing its effects by promoting enzyme activity and keratinocyte differentiation. Tretinoin may improve minoxidil's response by boosting the expression of necessary enzymes and transporters.

Related Research

6 / 6 results

research Possible Cellular Communication with Human Follicle Dermal Papilla Cells via Secretions from Human Hair Follicle Keratinocytes

January 2022 in “Journal of St. Marianna University”

Substances from human hair cells can affect hair loss-related genes, potentially leading to new treatments for baldness.

research A Model System to Analyze the Ability of Human Keratinocytes to Form Hair Follicles

15 citations, April 2014 in “Experimental Dermatology”

Scientists developed a system to study human hair growth using skin cells, which could help understand hair development and improve skin substitutes for medical use.

research Review of Hair Follicle Dermal Cells

321 citations, December 2009 in “Journal of Dermatological Science”

Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.