The Upper Dermal Sheath Has Potential to Regenerate Hair in Rat Follicular Epidermis

    September 1996 in “ Differentiation ”
    Takashi Matsuzaki, Mutsumi Inamatsu, Katsutoshi Yoshizato
    TLDR The upper dermal sheath can regenerate hair in rats.
    The study from 1996 demonstrated that the upper dermal sheath of a rat vibrissa follicle had the potential to regenerate hair, contrary to previous beliefs. When the upper halves of the follicles were implanted under the kidney capsule for 8 weeks, pelage-type hairs were produced. Monoclonal antibody analysis revealed the formation of small hair bulbs due to interactions between upper dermal sheath cells and follicular basal cells. These new bulbs formed at the amputated end and upper region of the follicles, but not near the bulge area where stem cells are located. The study suggested that while the hair-inducing ability of the upper dermal sheath was weaker compared to lower dermal compartments, it was still sufficient to induce hair production under specific conditions.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 550 results

      community A Different Take on Curing MBP

       16 upvotes 6 years ago
      Addressing hair loss by focusing on posture, blood flow, and craniofacial development. Methods include improving posture, cardiovascular activity, scalp massages, healthy diet, meditation, using minoxidil, and addressing craniofacial issues.

      community Dr Kyle Gillett on topical Dutasteride

      in Finasteride/Dutasteride  56 upvotes 2 years ago
      The potential effectiveness of topical dutasteride, as well as other hair loss treatments such as finasteride, RU58841, minoxidil, and various vitamins. Experiences from users who have used these treatments were shared.

      community Solo use of Pyrilutamide: UPDATE

      in Update  45 upvotes 2 years ago
      A user who has been using Pyrilutamide for 19 days, experiencing some hair thickening in the right temple and crown area but also having ball ache after microneedling; other users offer advice, caution and skepticism as to whether results can be seen in such a short time.

      community Dutasteride Mesotherapy Works – Just 1 month results

      in Progress Pictures  108 upvotes 3 years ago
      The effectiveness of using dutasteride mesotherapy as a hair loss treatment, with other protocols such as microneedling, vitamin D and B12, zinc, and biotin. The user's results were positive after 4-6 months without any serious side effects.

      community PP405 Update and My Take on Pelage

      in Research/Science  84 upvotes 4 weeks ago
      Pelage Pharmaceuticals raised $120M for their hair loss treatment, PP405, showing strong investor confidence despite limited data. There is skepticism about its efficacy and long-term effects compared to treatments like GT20029.

    Related Research

    7 / 7 results