Thrombospondin-1 Plays a Critical Role in the Induction of Hair Follicle Involution and Vascular Regression During the Catagen Phase

    January 2003 in “ Journal of Investigative Dermatology ”
    Kiichiro Yano, Michael Detmar, Lawrence F. Brown … Tokichi Miyakawa
    Studysummary This study found that thrombospondin-1 plays a critical role in hair follicle cycle regulation, with deficiency prolonging follicle growth and overexpression delaying it through antiangiogenic effects.
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    Research cited in this study 8

    1. Targeted Overexpression of the Angiogenesis Inhibitor Thrombospondin-1 in the Epidermis of Transgenic Mice Prevents Ultraviolet-B-Induced Angiogenesis and Cutaneous Photo-Damage Journal of Investigative Dermatology · 2002
    2. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001
    3. The Role of VEGF and Thrombospondins in Skin Angiogenesis Journal of Dermatological Science · 2000
    4. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    5. Loss of Vascular Endothelial Growth Factor in Human Alopecia Hair Follicles Journal of Investigative Dermatology · 1995
    6. The Secret Life of the Hair Follicle Trends in genetics · 1992
    7. Circulatory Changes in Alopecia Archives of Dermatology · 1961
    8. Growth of the Hair Physiological Reviews · 1954