Thrombospondin-1 Plays a Critical Role in the Induction of Hair Follicle Involution and Vascular Regression During the Catagen Phase

January 2003 in “ Journal of Investigative Dermatology ”

Kiichiro Yano, Michael Detmar, Lawrence F. Brown, Jack Lawler, Tokichi Miyakawa

thrombospondin-1 TSP-1 hair follicle cycling catagen phase antiangiogenic factor vascular regression hair follicle involution perifollicular vascularization anagen phase angiogenesis

Studysummary This study found that thrombospondin-1 plays a critical role in hair follicle cycle regulation, with deficiency prolonging follicle growth and overexpression delaying it through antiangiogenic effects.

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