The Role of VEGF and Thrombospondins in Skin Angiogenesis

The document discussed the role of vascular endothelial growth factor (VEGF) and thrombospondins in skin angiogenesis. It highlighted that while adult skin vasculature is typically inactive due to angiogenesis inhibitors, it can rapidly initiate angiogenesis during tissue repair and in diseases like psoriasis and skin cancers. VEGF was identified as a key factor in promoting skin angiogenesis, particularly during the hair follicle growth phase, while VEGF-C was linked to skin lymphangiogenesis. Thrombospondin-1 and thrombospondin-2 were noted as significant angiogenesis inhibitors, maintaining vascular quiescence and inhibiting tumor growth. The study suggested that targeting blood vessels could be a promising therapeutic strategy for various skin diseases.