Generating Detailed Intercellular Communication Patterns in Psoriasis at the Single-Cell Level Using Social Networking, Pattern Recognition, and Manifold Learning Methods to Optimize Treatment Strategies

    January 2024 in “ Aging ”
    Ying Xiang, Sidi Li, Yunmeng Bai … Bo Wu
    Studysummary This study examined the molecular communication in psoriasis cells, highlighting unique immune cell interactions and identifying new features of the hair follicle cell-psoriasis axis. It suggests the potential for targeted therapies at the single-cell level to improve psoriasis treatment.
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    Research cited in this study 6

    1. Choreographing Immunity in the Skin Epithelial Barrier Immunity · 2019
    2. Sebaceous Gland Atrophy in Psoriasis: An Explanation for Psoriatic Alopecia? Journal of Investigative Dermatology · 2016
    3. Cyclosporin A Promotes Hair Epithelial Cell Proliferation and Modulates Protein Kinase C Expression and Translocation in Hair Epithelial Cells Journal of Investigative Dermatology · 2001
    4. The Role of VEGF and Thrombospondins in Skin Angiogenesis Journal of Dermatological Science · 2000
    5. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    6. The Human Hair Follicle: A Reservoir of CD40+ B7-Deficient Langerhans Cells That Repopulate Epidermis After UVB Exposure ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998