The Imbalance Between Type 17 T-Cells And Regulatory Immune Cell Subsets In Psoriasis Vulgaris

    August 2022 in “ Frontiers in Immunology ”
    Jaehwan Kim, Ariana Moreno, James G. Krueger
    TLDR Psoriasis involves an imbalance between certain immune cells, and targeting these could help restore skin health.
    The study explored the immunopathogenesis of psoriasis vulgaris, affecting 7.5 million adults in the US, focusing on the imbalance between Type 17 T-cells (T17 cells) and regulatory immune cell subsets. Advances in single-cell RNA sequencing allowed for detailed analysis of T17 cell subsets, revealing T-cell plasticity and the role of regulatory cytokines. The research highlighted the presence of various regulatory cells in the skin, such as type 1 regulatory T-cells and regulatory dendritic cells. Recent efforts aimed to apply single-cell technologies in clinical trials to assess if blocking pathogenic T-cells with biologics could promote the expansion of regulatory immune cells, potentially restoring skin homeostasis.
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