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research The imbalance between Type 17 T-cells and regulatory immune cell subsets in psoriasis vulgaris

49 citations , August 2022 in “Frontiers in Immunology”

This paper discusses the evolving understanding of psoriasis pathogenesis with no new clinical findings; the authors highlight the role of T-cell plasticity and regulatory cells, calling for further clinical applications using single-cell technologies.

research Dandruff Is a Low‐Grade Inflammatory Condition Featuring Hyperproliferative Keratinocytes, Interleukin‐17‐Producing T Cells, and N‐Acyl Ethanolamines

June 2026 in “Immunity Inflammation and Disease”

In this study, researchers observed that dandruff involves altered keratinocyte activity and a low-grade inflammatory response characterized by increased interleukin-17-producing T-cells and CCL17 levels, but without significant changes in immune cell populations or skin barrier lipids.

research Role of regulatory T cells in psoriasis pathogenesis and treatment

273 citations , July 2020 in “British Journal of Dermatology”

This review discusses recent insights into the role of regulatory T cells in psoriasis and the impact of current treatments on their function, but reports no new research findings.

research Alopecia areata is characterized by dysregulation in systemic type 17 and type 2 cytokines, which may contribute to disease‐associated psychological morbidity

57 citations , April 2019 in “British journal of dermatology/British journal of dermatology, Supplement”

This background review discusses alopecia areata, highlighting the role of CD8+NKG2D+ T cells in hair follicle pathogenesis, and notes that the exact mechanisms causing hair loss remain unclear.

research CD4 T cells from mice with alopecia areata express an effector like phenotype and can transfer disease

1 citations , May 2023 in “The Journal of Immunology”

In this animal study, researchers discovered that CD4 T cells from mice with alopecia areata can induce the disease more efficiently than those from unaffected mice, likely by supporting CD8 T cell activation and hair follicle attack.

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community Creatine Doesn’t Cause Hair Loss: Stop the BS

137 upvotes 11 months ago

Creatine does not cause hair loss, despite many users reporting personal experiences of hair shedding. Scientific evidence shows no link between creatine and increased hair loss or hormone changes.

community 23M Couldn’t go bald for fear of my Girlfriend leaving me.

1096 upvotes 1 year ago

A 23-year-old man uses a topical spray with minoxidil, finasteride, and tretinoin for hair loss, experiencing improved hair growth but occasional heart palpitations. He worries his girlfriend might leave him if he goes bald, but commenters advise that if she would leave over hair loss, she isn't worth it.

community Started balding at 17 im 19 now 1 year on min started fin today Best its looked in years

in Progress Pictures 75 upvotes 9 months ago

A 19-year-old shared progress on hair regrowth after using minoxidil for a year and starting finasteride. Users discussed the effectiveness and side effects of these treatments, with some expressing concerns about potential side effects and others sharing positive experiences.

community 1 year on fin. No results. I give up.

in Finasteride/Dutasteride 43 upvotes 3 years ago

A user who has been taking finasteride, minoxidil, and microneedling for one year with no results, and the replies discuss other treatments, including dutasteride, which is feared due to potential side effects.

community How come dutasteride doesn't lower allopregnanolone, but finasteride does?

12 upvotes 1 year ago

Finasteride significantly lowers allopregnanolone levels, while dutasteride's effect is less clear and may vary. Some users speculate that dutasteride might be healthier for the brain due to its different inhibition pathways.

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