Alopecia Areata Is Characterized by Dysregulation in Systemic Type 17 and Type 2 Cytokines, Which May Contribute to Disease-Associated Psychological Morbidity

    April 2019 in “ British journal of dermatology/British journal of dermatology, Supplement ”
    K.A. Bain, Elizabeth S. McDonald, Fiona Moffat, Mauro Tutino, Madhura Castelino, Anne Barton, Jonathan Cavanagh, Umer Zeeshan Ijaz, Stefan Siebert, Iain B. McInnes, Annika Åstrand, Susan Holmes, Simon Milling
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    TLDR Alopecia areata involves immune system imbalances that may lead to depression and anxiety.
    The study concluded that alopecia areata (AA) was associated with dysregulation in systemic type 17 and type 2 cytokines, including elevated levels of IL-17A, IL-17F, IL-21, IL-23, IL-33, IL-31, and IL-17E/25. This cytokine imbalance might contribute to the psychological morbidity, such as depression and anxiety, observed in AA patients. Specifically, IL-22 and IL-17E levels were positively correlated with depression scores. The study, which included 39 AA patients, suggested that therapeutic strategies should address the underlying immune dysregulation rather than focusing solely on the CD8+ T cell response.
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