Dermal T Cell Immunity and Key Regulatory Signaling Pathways: Implications in Immune-Mediated Alopecia and Hair Regeneration

    January 2025 in “ Genes & Diseases ”
    Nana Tao, Qingru Sun, Yuyuan Ying … Jian‐Li Gao
    Studysummary This review highlights that T cells are crucial in regulating hair follicle regeneration and their disruption can lead to alopecia, providing insights into hair disorders related to T cell immune balance and hair follicle regeneration.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on sciencedirect.com →
    Discuss this study in the Community →

    Research cited in this study 53

    1. Immune Niches for Hair Follicle Development and Homeostasis Frontiers in physiology · 2024
    2. Th22 Is the Effector Cell of Thymosin β15-Induced Hair Regeneration in Mice Inflammation and regeneration · 2024
    3. Local and Systemic Mechanisms That Control the Hair Follicle Stem Cell Niche Nature Reviews Molecular Cell Biology · 2023
    4. Tracing Immune Cells Around Biomaterials With Spatial Anchors During Large-Scale Wound Regeneration Nature Communications · 2023
    5. Identification of Immune Microenvironment Changes, Immune-Related Pathways and Genes in Male Androgenetic Alopecia Medicine · 2023
    6. Alopecia Areata: Current Treatments and New Directions American Journal of Clinical Dermatology · 2023
    7. Janus Kinase Inhibitors For Alopecia Areata JAMA network open · 2023
    8. The Potential of Regulatory T Cell-Based Therapies for Alopecia Areata Frontiers in Immunology · 2023
    9. Central Centrifugal Cicatricial Alopecia in Adolescents: Overview of Literature Life · 2023
    10. Overexpression of Hypoxia-Inducible Factor-1α in Hidradenitis Suppurativa: The Link Between Deviated Immunity and Metabolism Archives of dermatological research · 2023
    11. Thymosin Beta 4 and Actin: Binding Modes, Biological Functions and Clinical Applications Current Protein and Peptide Science · 2022
    12. Regenerative Medicine Strategies for Hair Growth and Regeneration: A Narrative Review of Literature Regenerative Therapy · 2022
    13. Hair-Growth-Promoting Effects of the Fish Collagen Peptide in Human Dermal Papilla Cells and C57BL/6 Mice Modulating Wnt/Beta-Catenin and BMP Signaling Pathways International Journal of Molecular Sciences · 2022
    14. Stem Cell Secretome as a Mechanism for Restoring Hair Loss Due to Stress, Particularly Alopecia Areata: Narrative Review Journal of Biomedical Science · 2022
    15. Frontal Fibrosing Alopecia: A Review of Disease Pathogenesis Frontiers in Medicine · 2022
    16. Autoantigen Discovery in the Hair Loss Disorder, Alopecia Areata: Implications of Post-Translational Modifications Frontiers in immunology · 2022
    17. Immune-Mediated Alopecias and Their Mechanobiological Aspects Cells and Development · 2022
    18. Intrinsic ROS Drive Hair Follicle Cycle Progression by Modulating DNA Damage and Repair and Subsequently Hair Follicle Apoptosis and Macrophage Polarization Oxidative Medicine and Cellular Longevity · 2022
    19. Ritlecitinib And Brepocitinib Demonstrate Significant Improvement In Scalp Alopecia Areata Biomarkers ˆThe ‰journal of allergy and clinical immunology/Journal of allergy and clinical immunology/˜The œjournal of allergy and clinical immunology · 2021
    20. Differentiation of Frontal Fibrosing Alopecia and Lichen Planopilaris on Trichoscopy: A Comprehensive Review Journal of Cosmetic Dermatology · 2021
    21. Hair Follicle Stem Cells as a Skin-Organizing Signaling Center During Adult Homeostasis The EMBO Journal · 2021
    22. Bacteria Induce Skin Regeneration via IL-1β Signaling Cell Host & Microbe · 2021
    23. Functional Hair Follicle Regeneration: An Updated Review Signal Transduction and Targeted Therapy · 2021
    24. Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata Experimental dermatology · 2020
    25. Oral Minoxidil Treatment for Hair Loss: A Review of Efficacy and Safety Journal of The American Academy of Dermatology · 2020
    26. A Transcriptomic Map of Murine and Human Alopecia Areata JCI Insight · 2020
    27. Immune Modulation of Hair Follicle Regeneration npj Regenerative Medicine · 2020
    28. Pathomechanisms of Immune-Mediated Alopecia International Immunology · 2019
    29. Alopecia Diffusa While Using Interleukin-17 Inhibitors Against Psoriasis Vulgaris Case Reports in Dermatology · 2019
    30. Lichen Planopilaris and Frontal Fibrosing Alopecia as Model Epithelial Stem Cell Diseases Trends in Molecular Medicine · 2018
    31. T Helper 17 Cell/Regulatory T-Cell Imbalance in Hidradenitis Suppurativa/Acne Inversa: The Link to Hair Follicle Dissection, Obesity, Smoking, and Autoimmune Comorbidities British journal of dermatology/British journal of dermatology, Supplement · 2018
    32. Immune Privilege Collapse And Alopecia Development: Is Stress A Factor Skin Appendage Disorders · 2017
    33. Regulatory T Cells in Skin: Role of Foxp3+ CD4+ Tregs in Skin Homeostasis and Immune Tolerance Immunology · 2017
    34. Regulating Hair Follicle Stem Cells Immunity · 2017
    35. CD80CD86 Deficiency Disrupts Regulatory CD4+FoxP3+ T Cell Homeostasis and Induces Autoimmune-Like Alopecia Experimental dermatology · 2017
    36. Central Centrifugal Cicatricial Alopecia: Challenges and Solutions Clinical, Cosmetic and Investigational Dermatology · 2016
    37. Hair Follicle-Derived IL-7 and IL-15 Mediate Skin-Resident Memory T Cell Homeostasis and Lymphoma Nature medicine · 2015
    38. The Role of Lymphocytes in the Development and Treatment of Alopecia Areata Expert Review of Clinical Immunology · 2015
    39. Cyclosporine A Increases Hair Follicle Growth by Suppressing Apoptosis-Inducing Factor Nuclear Translocation: A New Mechanism Fundamental & clinical pharmacology · 2015
    40. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    41. The Role of Hair Follicle Immune Privilege Collapse in Alopecia Areata: Status and Perspectives Journal of Investigative Dermatology Symposium Proceedings · 2013
    42. A New Humanized Mouse Model For Alopecia Areata Journal of Investigative Dermatology Symposium Proceedings · 2013
    43. Lichen Planopilaris Is Characterized By Immune Privilege Collapse Of The Hair Follicle's Epithelial Stem Cell Niche The Journal of Pathology · 2013
    44. Recent Advances in the Pathogenesis of Autoimmune Hair Loss Disease Alopecia Areata Clinical and Developmental Immunology · 2013
    45. Comparative Secretome Analysis of Human Follicular Dermal Papilla Cells and Fibroblasts Using Shotgun Proteomics BMB Reports · 2012
    46. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010
    47. Frontal Fibrosing Alopecia: Clinical Presentations and Prognosis British journal of dermatology/British journal of dermatology, Supplement · 2008
    48. Maintenance of Hair Follicle Immune Privilege Is Linked to Prevention of NK Cell Attack Journal of Investigative Dermatology · 2007
    49. The Pathogenesis of Alopecia Areata in Rodent Models Journal of Investigative Dermatology Symposium Proceedings · 2003
    50. Identification of Clustered Cells in Human Hair Follicle Responsible for MMP-9 Gelatinolytic Activity: Consequences for the Regulation of Hair Growth International Journal of Dermatology · 2001
    51. Role of Cytotoxic T Cells in Chronic Alopecia Areata Journal of Investigative Dermatology · 2000
    52. Fortnightly Review: Male Pattern Androgenetic Alopecia BMJ · 1998
    53. Male Pattern Alopecia: A Histopathologic and Histochemical Study Journal of Cutaneous Pathology · 1975