A Transcriptomic Map of Murine and Human Alopecia Areata

May 2020 in “ JCI Insight ”

Nicholas Borcherding, Sydney Crotts, Luana dos Santos Ortolan, Nicholas Henderson, Nicholas L. Bormann, Ali Jabbari

alopecia areata autoimmune condition single-cell sequencing immune cell expression profiles CD4+ T cells CD8+ T cells clonal expansions transcriptional states pathogenesis predictive models therapeutic intervention AA immune system T cells

TLDR Alopecia areata involves specific immune cells, offering potential treatment targets.

The study investigated the autoimmune condition alopecia areata (AA) using single-cell sequencing to map immune cell expression profiles in both mice and humans. It revealed clonal expansions of CD4+ and CD8+ T cells, with shared clonotypes across different transcriptional states, highlighting the involvement of both cell types in AA pathogenesis. The murine data were used to create predictive models for human AA, which were validated by similar findings in human T cells. This research provided insights into the immune mechanisms of AA and suggested potential targets for therapeutic intervention.

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Research cited in this study

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