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Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition

research Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition

174 citations , November 2016 in “Cell stem cell”

Different types of skin cells have unique genetic markers that affect how likely they are to spread cancer.

research A Transcriptomic Map of Murine and Human Alopecia Areata

26 citations , May 2020 in “JCI Insight”

Alopecia areata involves specific immune cells, offering potential treatment targets.

research Multi-Tasking Epidermal Stem Cells: Beyond Epidermal Maintenance

23 citations , November 2018 in “Development, Growth & Differentiation”

Epidermal stem cells have various roles in skin beyond just maintenance, including forming specialized structures and aiding in skin repair and regeneration.

research Deciphering the Mesodermal Potency of Porcine Skin-Derived Progenitors by Microarray Analysis

6 citations , April 2010 in “Cellular Reprogramming”

Pig skin cells can turn into mesodermal cells but lose their ability to become neural cells.

research The Harmonies Played by TGF-β in Stem Cell Biology

156 citations , December 2012 in “Cell Stem Cell”

TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.

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community What happened to the ‘funding’ for broccoli research in treating hair loss?

in Chat 42 upvotes 4 years ago

Hair loss discussion includes broccoli sprouts treatment, Fluridil 7%, and sulforaphane, with mixed results. Finasteride, minoxidil, and RU58841 are preferred by some users.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 681 upvotes 1 year ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community Testosterone in Reference Range Doesn't Cause Hair Loss

in Research/Science 50 upvotes 1 year ago

Testosterone within the normal range does not significantly contribute to male pattern baldness (MPB); DHT is the main factor that can be controlled. Genetics play a crucial role in hair loss, and treatments like finasteride and dutasteride, which block DHT, can help despite potentially raising testosterone levels.

community Minoxidil Response Bottlenecks: Why Sulfation and Transport Matter (And Where Tretinoin Fits In)

in Research 461 upvotes 5 months ago

Minoxidil's effectiveness is limited by the need for sulfation and proper transport to hair follicles, with tretinoin potentially enhancing its effects by promoting enzyme activity and keratinocyte differentiation. Tretinoin may improve minoxidil's response by boosting the expression of necessary enzymes and transporters.

community 50% test increase after 18 months of taking DUT

in Update 57 upvotes 1 year ago

A user reported a 50% increase in testosterone after 18 months of taking dutasteride for hair loss. The conversation includes skepticism about the reliability of single testosterone tests and questions about estrogen levels.

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