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GlossaryCD8+ T cells

specialized immune cells that destroy infected or cancerous cells

CD8+ T cells, also known as cytotoxic T cells or killer T cells, are a type of white blood cell that plays a crucial role in the immune system. They are responsible for identifying and destroying infected or cancerous cells by recognizing specific antigens presented on the surface of these cells.

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Diffuse Alopecia Areata Is Associated With Intense Inflammatory Infiltration and CD8+ T Cells in Hair Loss Regions and an Increase in Serum IgE Level

research Diffuse Alopecia Areata Is Associated With Intense Inflammatory Infiltration and CD8+ T Cells in Hair Loss Regions and an Increase in Serum IgE Level

24 citations, January 2012 in “Indian Journal of Dermatology, Venereology and Leprology”

Diffuse alopecia areata involves more inflammation and higher allergy-related antibodies than patchy types.

research Braicitinib Treatment Reduced the Expansion of CD8+ T Cells in C3H Mice With Skin Grafts-Induced Alopecia Areata

October 2023 in “Regular and Young Investigator Award Abstracts”

Baricitinib treatment helped reduce hair loss symptoms in mice by decreasing inflammation-related immune cells.

Expression of Programmed Cell Death 1 Inversely Correlated With the Density of CD8+ T Cells Infiltrating Hair Follicles in Alopecia Areata

research Expression of Programmed Cell Death 1 Inversely Correlated With the Density of CD8+ T Cells Infiltrating Hair Follicles in Alopecia Areata

April 2023 in “Journal of Investigative Dermatology”

Higher PD-1 levels are linked to fewer immune cells in hair follicles in alopecia areata.

research Phosphodiesterase Inhibitors Could Reverse the Proliferation of BPH Epithelial Cells Induced by CD8+ T Cells in Low Androgen Condition

April 2018 in “The Journal of Urology”

Phosphodiesterase inhibitors like tadalafil can reduce cell growth in BPH caused by CD8+ T cells in low androgen conditions.

research High-Throughput T Cell Receptor Sequencing Identifies Clonally Expanded CD8+ T Cell Populations in Alopecia Areata

46 citations, October 2018 in “JCI insight”

CD8+ T cells are involved in alopecia areata and may cause disease relapse.

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