TLDR People with alopecia areata have fewer regulatory T-cells than those with other skin conditions.
The study investigated the role of regulatory T-cells (Treg) in alopecia areata (AA) by examining the presence of CD4+FoxP3+, CD25+FoxP3+, and CD8+FoxP3+ Treg in 12 AA cases compared to 12 other autoimmune and non-autoimmune cutaneous diseases using immunohistochemical staining. Results showed a significant reduction in the mean frequency of CD4+FoxP3+ and CD25+FoxP3+ Treg in AA compared to other diseases. This suggests that Treg is significantly lower in AA, which may have implications for future interventions. The immunohistochemical-staining protocol used could also be useful for evaluating Treg in other cutaneous diseases.
62 citations,
June 2015 in “The Journal of Dermatology” People with alopecia areata have more Th17 cells and fewer Treg cells, which may be key to the condition's development.
May 2023 in “Frontiers in Immunology” Treg cell-based therapies might help treat hair loss from alopecia areata, but more research is needed to confirm safety and effectiveness.
125 citations,
September 2019 in “Journal of Clinical Immunology” Foxp3 is crucial for regulatory T cell function, and targeting these cells may help treat immune disorders.
30 citations,
July 2019 in “PloS one” Patients with Alopecia areata have fewer specific immune cells that normally regulate the immune system, which may contribute to the condition.
2 citations,
September 2022 in “Frontiers in Immunology” T-regulatory cells are important for skin health and can affect hair growth and reduce skin inflammation.
29 citations,
May 2020 in “npj Regenerative Medicine” Immune cells help regulate hair growth, and better understanding this can improve hair loss treatments.
