Regulatory T-Cells in Alopecia Areata

    April 2019 in “ Journal of cutaneous pathology ”
    Jodi Speiser, Dana M Mondo, Vikas Mehta, Sheela A Marcial, Ameet R. Kini, Kelli A. Hutchens
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    Studysummary This study found a significant reduction in Treg cell frequency in alopecia areata compared to other autoimmune and non-autoimmune skin diseases using immunohistochemical staining.
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    The study investigated the role of regulatory T-cells (Treg) in alopecia areata (AA) by examining the presence of CD4+FoxP3+, CD25+FoxP3+, and CD8+FoxP3+ Treg in 12 AA cases compared to 12 other autoimmune and non-autoimmune cutaneous diseases using immunohistochemical staining. Results showed a significant reduction in the mean frequency of CD4+FoxP3+ and CD25+FoxP3+ Treg in AA compared to other diseases. This suggests that Treg is significantly lower in AA, which may have implications for future interventions. The immunohistochemical-staining protocol used could also be useful for evaluating Treg in other cutaneous diseases.
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