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Glossary Regulatory T Cells

specialized immune cells that prevent autoimmune responses

Regulatory T Cells, often abbreviated as Tregs, are a specialized subset of T cells in the immune system that help maintain immune tolerance and prevent autoimmune diseases. They function by suppressing the activity of other immune cells, thereby preventing excessive or misdirected immune responses that could damage the body's own tissues.

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Research

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research Role of regulatory T cells in psoriasis pathogenesis and treatment

273 citations , July 2020 in “British Journal of Dermatology”

This review discusses recent insights into the role of regulatory T cells in psoriasis and the impact of current treatments on their function, but reports no new research findings.

research Regulatory T-Cells: Potential Regulator of Tissue Repair and Regeneration

188 citations , March 2018 in “Frontiers in Immunology”

This review discusses the role of regulatory T-cells in tissue repair and regeneration across various organs and reports no new clinical results.

research Regulatory T Cells: the Many Faces of Foxp3

125 citations , September 2019 in “Journal of Clinical Immunology”

This review summarizes recent advances in Treg cell biology, focusing on Foxp3's role in immune regulation and therapeutic reprogramming for immune dysregulatory disorders, but reports no new clinical results.

Regulatory T Cells in Skin: Role of Foxp3+ CD4+ Tregs in Skin Homeostasis and Immune Tolerance

research Regulatory T cells in skin

110 citations , July 2017 in “Immunology”

This review discusses the role of regulatory T cells in skin, including their impact on hair follicle regeneration, wound healing, and immune tolerance, without presenting new clinical findings.

research Transient CD44 Variant Isoform Expression and Reduction in CD4+/CD25+ Regulatory T Cells in C3H/HeJ Mice with Alopecia Areata

77 citations , June 2002 in “Journal of Investigative Dermatology”

CD44 variant changes start alopecia areata, but don't maintain it.

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Community Join

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community HairClone (UK) finally begins offering its Dermal Papilla Cell Hair Multiplication procedure to humans. In Guatemala.

149 upvotes 6 months ago

HairClone is offering a Dermal Papilla Cell Hair Multiplication procedure in Guatemala, raising questions about its effectiveness and regulatory reasons for the location. Users express skepticism and curiosity about the treatment's success and potential costs.

community Mallia Aesthetics achieves key regulatory steps for novel sCD83-derived ingredient for hair growth

24 upvotes 1 year ago

Mallia Aesthetics has developed MAL-838, a hormone-free product derived from sCD83, which stimulates hair growth without disrupting the skin microbiome. sCD83 promotes hair growth by activating hair follicles and preventing cell death, offering a localized treatment without systemic side effects.

community HairClone developing cell replacement treatments for Hair Loss

5 upvotes 7 years ago

HairClone is developing cell replacement treatments to rejuvenate and generate hair follicles, and has launched a crowdfunding campaign. A user expressed skepticism about the need for crowdfunding.

community Good news for stem cells hair therapies - US federal judge: using patients' stem cells does NOT fall under FDA jurisdiction

26 upvotes 4 years ago

A US federal judge ruled that using patients' stem cells for medical treatments is not under FDA jurisdiction, potentially speeding up development of stem cell-based hair loss therapies. Some users are optimistic about increased research and development, while others express skepticism about the ruling's impact on safety and efficacy standards.

community Wouldn’t it be funny if there already was a drug that existed which reactivated sleeping follicles? It would be our own version of Ozempic

202 upvotes 1 year ago

PP405 shows promise for reactivating hair follicles, with potential maintenance using 5AR inhibitors. Current treatments like Minoxidil and finasteride are effective but have limitations, and there is hope for more effective solutions in the future.

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diabetes drug with anti-inflammatory, immunomodulatory, and insulin-sensitizing properties

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Is a hair transplant in Turkey safe? Clinics in Turkey describe their own work as safe when it is done in a licensed clinic by an experienced surgeon, and they also agree that quality varies a lot between clinics. All of that comes from the clinics themselves rather than from independent regulator or complication data, so any judgement rests on the specific clinic and surgeon, not on the country.

learn tamsulosin

Is tamsulosin linked to hair thinning or hair improvement as a side effect? Published tamsulosin trials, the product label and regulatory reviews do not establish a link to hair thinning, and no controlled study supports it as a hair-growth treatment; scattered post-marketing reports of alopecia exist but are not evidence of cause.

learn Valproic acid

Why is valproic acid not considered a standard cosmetic ingredient despite its potential effects on hair growth? Valproic acid is not a standard cosmetic ingredient due to safety and regulatory concerns.

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