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Glossary Apoptosis Regulator

protein controlling programmed cell death in cells

An apoptosis regulator, also known as a cell death regulator, is a protein that controls the process of apoptosis, which is the programmed death of cells. This process is crucial for maintaining healthy tissue by eliminating damaged or unnecessary cells. Dysregulation of apoptosis can lead to diseases such as cancer, where cells avoid death and proliferate uncontrollably, or degenerative diseases, where excessive cell death occurs.

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Research

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Ginsenoside F2 Reduces Hair Loss by Controlling Apoptosis Through the Sterol Regulatory Element-Binding Protein Cleavage Activating Protein and Transforming Growth Factor-β Pathways in a Dihydrotestosterone-Induced Mouse Model

research Ginsenoside F2 Reduces Hair Loss by Controlling Apoptosis through the Sterol Regulatory Element-Binding Protein Cleavage Activating Protein and Transforming Growth Factor-β Pathways in a Dihydrotestosterone-Induced Mouse Model

22 citations , January 2014 in “Biological & Pharmaceutical Bulletin”

This study found that ginsenoside F2 may suppress hair cell apoptosis and improve hair growth outcomes in a DHT-induced hair loss model more effectively than finasteride.

research Evaluation of apoptosis regulatory markers in androgenetic alopecia

6 citations , December 2010 in “Journal of Cosmetic Dermatology”

This study suggests that low proliferation rates in bald areas of androgenetic alopecia patients, along with persistent inflammatory infiltrate, may lead to follicular miniaturization and fibrosis.

research Topical ALA-Photodynamic Therapy for Acne Can Induce Apoptosis of Sebocytes and Down-regulate Their TLR-2 and TLR-4 Expression

37 citations , January 2011 in “Annals of Dermatology”

In this study, photodynamic therapy significantly reduced inflammatory acne lesions and sebum secretion, possibly by inducing apoptosis in sebaceous glands and down-regulating TLR-2 and TLR-4 expression.

P21Waf1/Cip1 Is Differentially Expressed in Epidermal Versus Follicular Melanocytes and Melanoma Cells and Is Phenotypically Regulated by UVB-Mediated Apoptosis

research 1272 p21Waf1/Cip1 is differentially expressed in epidermal versus follicular melanocytes and melanoma cells and is phenotypically regulated by UVB-mediated apoptosis

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that p21 is much more highly expressed in normal melanocytes compared to melanoma cells, suggesting a potential target for preventing melanoma progression through cell cycle repair processes.

research Regulatory T Cells in Autoimmune Diseases and their Potential

3 citations , November 2005 in “Journal of Investigative Dermatology Symposium Proceedings”

Enhancing regulatory T cells may help treat autoimmune diseases like alopecia areata.

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Community Join

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community Prolactin the Cause of Hair Loss? ABS-201 the Cure?

29 upvotes 2 months ago

Prolactin may contribute to hair loss, but targeting its receptor won't cure androgenetic alopecia. ABS-201 could be a useful alternative or adjuvant therapy, similar to JAK inhibitors, but not more effective than HMI-115.

community I hope ET-02 or PP405 will be released in the next 4-5 years

18 upvotes 1 year ago

PP405 is a potential hair loss treatment that may work by blocking signals that cause hair cells to stop growing, requiring daily application for effectiveness. It could serve as an alternative to minoxidil and finasteride, but it is not yet available on the market and may take several years to be released.

community 2 % fucoidan significantly alleviated AGA symptoms, promoted hair growth, and increased hair density

21 upvotes 11 months ago

2% fucoidan alleviated AGA symptoms, promoted hair growth, and increased hair density in mice. Fucoidan is considered safe for humans as a supplement and topical skincare product, with potential therapeutic effects against AGA.

community Anti-oxidants that reverse hairloss?

86 upvotes 5 years ago

Resveratrol and fisetin, found in red wine and strawberries, may promote hair growth by affecting hair follicle cells. Users discuss various treatments, including natural remedies like saw palmetto and topical applications, with mixed opinions on their effectiveness compared to pharmaceuticals like finasteride.

community Everything you ever wanted to know about Pelage Pharma's PP405: how it works and what to expect

126 upvotes 3 months ago

PP405 may encourage earlier hair growth and slightly increase visible hair count but does not reverse hair follicle miniaturization in male pattern baldness. It does not address damage to the dermal papilla or broken Wnt signaling.

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Learn

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learn Melatonin

hormone commonly taken for sleep aid has some topical benefits for hair

learn Procyanidin

bioflavonoid found in plants with antioxidant and hair stimulating properties

learn GHK-Cu

a copper peptide showing promise in both regrowth and reversing gray hair

learn Overview

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