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    Did you mean Programmed Cell Death Protein 1?
    Glossary Programmed Cell Death Protein 1

    regulates immune response by inhibiting T cell activity

    Programmed Cell Death Protein 1 (PD-1) is a protein found on the surface of immune cells, such as T cells. It plays a crucial role in regulating the immune system by preventing overactivation, which can lead to autoimmune diseases. PD-1 achieves this by binding to its ligands, PD-L1 and PD-L2, which are often expressed on cancer cells, thereby inhibiting the immune response against these cells. This mechanism is a target for cancer immunotherapy, where blocking PD-1 can enhance the body's ability to fight cancer.

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    1. Expression patterns of programmed cell death 4 protein in normal human skin and some representative skin lesions Experimental Dermatology · 2007 · 37 citations
    2. ISID1373 - Expression of programmed cell death 1 inversely correlated with the density of CD8+ T cells infiltrating hair follicles in alopecia areata 2023
    3. 1373 Expression of programmed cell death 1 inversely correlated with the density of CD8+ T cells infiltrating hair follicles in alopecia areata Journal of Investigative Dermatology · 2023
    4. Anti-programmed cell death protein 1-induced lichenoid changes of the nail unit: Histopathologic description JAAD Case Reports · 2021 · 12 citations
    5. Hair Follicle Mesenchyme-Associated PD-L1 Regulates T-Cell Activation Induced Apoptosis: A Potential Mechanism of Immune Privilege Journal of Investigative Dermatology · 2013 · 53 citations
    6. Higher PDCD4 expression is associated with obesity, insulin resistance, lipid metabolism disorders, and granulosa cell apoptosis in polycystic ovary syndrome Fertility and Sterility · 2016 · 34 citations
    7. Persistently curly hair phenotype with the use of nivolumab for squamous cell lung cancer Journal of oncology pharmacy practice · 2016 · 19 citations
    8. Cell Density-Dependent Upregulation of PDCD4 in Keratinocytes and Its Implications for Epidermal Homeostasis and Repair International Journal of Molecular Sciences · 2015 · 10 citations
    9. Differences in cell subsets between sun-exposed and unexposed skin: preliminary single-cell sequencing and biological analysis from a single case Frontiers in Medicine · 2024 · 3 citations
    10. Cell death by cornification Biochimica et biophysica acta. Molecular cell research · 2013 · 375 citations
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