Expression Patterns of Programmed Cell Death 4 Protein in Normal Human Skin and Some Representative Skin Lesions

    February 2007 in “ Experimental Dermatology ”
    Sachiko Matsuhashi, Yutaka NARISAWA, Iwata Ozaki, Toshihiko Mizuta
    TLDR Increasing PDCD4 protein may help prevent or treat some skin cancers.
    The study examined the expression of the programmed cell death 4 (PDCD4) protein in normal human skin and various skin lesions, finding it primarily in the suprabasal layer of the epidermis and the outer root sheath of hair follicles. PDCD4 expression was reduced or absent in skin lesions like seborrheic keratosis and carcinomas. Growth factors such as EGF, TGF-β1, and HGF were found to downregulate PDCD4 in keratinocytes, suggesting environmental influence on its expression. The study suggested PDCD4's potential role in keratinocyte differentiation and apoptosis, and its low expression in carcinoma cell lines indicated its potential as a target for cancer prevention and therapy. Further research was recommended on PDCD4's role in hair follicle phases and regulation by dermal factors.
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