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GlossaryCaspase-8

enzyme initiating programmed cell death, crucial for tissue health

Caspase-8 is an enzyme that plays a crucial role in the process of programmed cell death, also known as apoptosis. It acts as an initiator caspase, meaning it helps to trigger the cascade of events that lead to cell death, which is essential for maintaining healthy tissue by removing damaged or unnecessary cells.

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research Effect of 5α-Dihydrotestosterone and Testosterone on Apoptosis in Human Dermal Papilla Cells

58 citations, January 2006 in “Skin Pharmacology and Physiology”

High levels of testosterone and 5α-DHT can lead to cell death in cells important for hair growth.

research Beneficial Effects of Astragaloside IV for Hair Loss via Inhibition of Fas/FasL-Mediated Apoptotic Signaling

29 citations, March 2014 in “PloS one”

Astragaloside IV may help prevent hair loss by blocking a specific pathway that leads to cell death.

research Notch Signaling Is Significantly Suppressed in Basal Cell Carcinomas and Activation Induces Basal Cell Carcinoma Cell Apoptosis

18 citations, February 2017 in “Molecular Medicine Reports”

Activating Notch signaling can kill basal cell carcinoma cells.

Complex Changes in the Apoptotic and Cell Differentiation Programs During Initiation of the Hair Follicle Response to Chemotherapy

research Complex Changes in the Apoptotic and Cell Differentiation Programs During Initiation of the Hair Follicle Response to Chemotherapy

12 citations, July 2014 in “Journal of Investigative Dermatology”

Chemotherapy causes complex changes in hair follicle cells that can lead to hair loss.

research Topical Treatment of Hair Loss with Formononetin by Modulating Apoptosis

10 citations, January 2016 in “Planta Medica”

Formononetin, found in red clover plants, can promote hair regrowth and reduce hair loss by preventing cell death.

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community Hair loss causes are still a myth.

in Chat 16 upvotes 3 years ago

The conversation discusses the complexity of hair loss causes, suggesting that DHT sensitivity alone doesn't fully explain it. Treatments mentioned include finasteride and dutasteride.