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Glossary Caspase-9

enzyme initiating programmed cell death in response to damage

Caspase-9 is an enzyme that plays a crucial role in the process of apoptosis, which is the programmed cell death essential for maintaining healthy tissue and organ function. It is activated in response to cellular stress or damage and initiates a cascade of events leading to the orderly dismantling of the cell. This enzyme is also known as Apoptotic protease Mch-6 and is vital for preventing the accumulation of damaged or potentially cancerous cells.

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Assessment of the Effect of Ficus Carica Leaf Extract on B16F10 Melanoma Cancer Cells: The Roles of p53, Caspase-3, and Caspase-9 in Inducing Intrinsic Apoptosis Cascade

research Assessment the Effect of Ficus carica Leaf Extract on B16F10 Melanoma Cancer Cells: The Roles of p53, Caspase-3 & Caspase-9 on Induction of Intrinsic Apoptosis Cascade

1 citations , October 2021 in “Jundishapur Journal of Natural Pharmaceutical Products”

This study found that methanolic extract of Ficus carica leaves induced apoptosis and inhibited proliferation in B16F10 melanoma cells, suggesting potential anti-cancer properties for further investigation in melanoma.

research Shen-Ying-Yang-Zhen formula promotes angiogenesis around hair follicles, alleviates oxidative stress, and inhibits hair follicle apoptosis through the VEGF/Akt/Caspase-9 signaling axis

June 2025 in “Phytomedicine”

The formula may improve hair growth and health by boosting blood flow and reducing cell stress.

Caspases in Life and Death: Their Role in Head Formation

research Making the head: Caspases in life and death

7 citations , January 2023 in “Frontiers in Cell and Developmental Biology”

This review provides a comprehensive overview of apoptosis-related molecules in head development, highlighting caspases' roles and associated abnormalities in tissues like the brain, sensory organs, skin, and bones, without reporting new results.

research 647 NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing caspase-3 activity in human melanoma

1 citations , April 2016 in “Journal of Investigative Dermatology”

This study found that NLRP1 in human melanoma cells promotes tumor growth by enhancing inflammasome activation and suppressing caspase-3 activity.

research Beneficial Effects of Astragaloside IV for Hair Loss via Inhibition of Fas/Fas L-Mediated Apoptotic Signaling

29 citations , March 2014 in “PloS one”

In this study, Astragaloside IV was found to inhibit apoptosis-related pathways in hair follicles of mice, suggesting it may serve as an alternative therapy for hair loss.

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