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GlossaryCaspase-9

enzyme initiating programmed cell death in response to damage

Caspase-9 is an enzyme that plays a crucial role in the process of apoptosis, which is the programmed cell death essential for maintaining healthy tissue and organ function. It is activated in response to cellular stress or damage and initiates a cascade of events leading to the orderly dismantling of the cell. This enzyme is also known as Apoptotic protease Mch-6 and is vital for preventing the accumulation of damaged or potentially cancerous cells.

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Assessment of the Effect of Ficus Carica Leaf Extract on B16F10 Melanoma Cancer Cells: The Roles of p53, Caspase-3, and Caspase-9 in Inducing Intrinsic Apoptosis Cascade

research Assessment of the Effect of Ficus Carica Leaf Extract on B16F10 Melanoma Cancer Cells: The Roles of p53, Caspase-3, and Caspase-9 in Inducing Intrinsic Apoptosis Cascade

1 citations, October 2021 in “Jundishapur Journal of Natural Pharmaceutical Products”

Ficus carica leaf extract may help treat melanoma by promoting cancer cell death without harming normal cells.

research NLRP1 Promotes Tumor Growth by Enhancing Inflammasome Activation and Suppressing Caspase-3 Activity in Human Melanoma

1 citations, April 2016 in “Journal of Investigative Dermatology”

NLRP1 helps melanoma tumors grow by boosting inflammasome activation and reducing caspase-3 activity.

research Endocrinology and Metabolism News, August 2005: Effects of Finasteride on Benign Prostatic Hyperplasia Tissues

6 citations, August 2005 in “The Journal of Clinical Endocrinology & Metabolism”

Finasteride causes temporary cell death in BPH tissues.

research Caspases in Life and Death: Their Role in Head Formation

7 citations, January 2023 in “Frontiers in Cell and Developmental Biology”

Caspases are enzymes important for both cell death and various non-lethal cell functions, affecting head development and hair growth, with different caspases playing specific roles.

research Apoptotic Cells Represent a Dynamic Stem Cell Niche Governing Proliferation and Tissue Regeneration

25 citations, June 2021 in “Developmental Cell”

Dying cells can help with faster healing and new hair growth by releasing a growth-promoting molecule.

research Dexpanthenol Promotes Cell Growth by Preventing Cell Senescence and Apoptosis in Cultured Human Hair Follicle Cells

13 citations, September 2021 in “Current Issues in Molecular Biology”

Dexpanthenol helps human hair follicle cells grow by preventing aging and death, and by supporting growth signals.

research Beneficial Effects of Astragaloside IV for Hair Loss via Inhibition of Fas/FasL-Mediated Apoptotic Signaling

29 citations, March 2014 in “PloS one”

Astragaloside IV may help prevent hair loss by blocking a specific pathway that leads to cell death.

research Partial Purification and Characterization of Two Distinct Types of Caspases from Human Epidermis

28 citations, September 1998 in “Journal of Investigative Dermatology”

Two distinct caspases in human skin help with cell death and skin formation.

research Tetrahydroxystilbene Glucoside Effectively Prevents Apoptosis-Induced Hair Loss

9 citations, January 2018 in “BioMed Research International”

Tetrahydroxystilbene Glucoside may help prevent hair loss by blocking certain pathways that lead to cell death.

12-O-Tetradecanoylphorbol-13-Acetate Induces Apoptosis in Renal Epithelial Cells Through a Growth Signal Conflict Prevented by Activated Ras

research 12-O-Tetradecanoylphorbol-13-Acetate Induces Apoptosis in Renal Epithelial Cells Through a Growth Signal Conflict Prevented by Activated Ras

4 citations, January 2001 in “Archives of Biochemistry and Biophysics”

Activated ras can protect kidney cells from a certain substance that causes cell death.

research Effects of Finasteride on Apoptosis and Regulation of the Human Hair Cycle

21 citations, January 2002 in “Journal of Cutaneous Medicine and Surgery”

Finasteride affects hair growth by changing caspase and XIAP levels, potentially treating hair diseases.

research Protective Effects of BCC Against Oxidative Stress in Cardiomyocyte Cells

March 2024 in “Journal of Experimental & Biomedical Sciences/Biomedical Science Letters”

BCC can protect heart cells from damage caused by oxidative stress.

Forsythiaside A Protects Against Focal Cerebral Ischemic Injury by Mediating the Activation of the Nrf2 and Endoplasmic Reticulum Stress Pathways

research Forsythiaside A Protects Against Focal Cerebral Ischemic Injury by Mediating the Activation of the Nrf2 and Endoplasmic Reticulum Stress Pathways

12 citations, May 2019 in “Molecular Medicine Reports”

Forsythiaside A helps reduce brain damage from lack of blood flow by activating certain protective pathways.

research Uncovering the Role of UV Exposure History and Genetics in Determining Skin Sun Damage

1 citations, April 2016 in “Journal of Investigative Dermatology”

UV photography can help identify people at higher risk for skin cancer, and male pattern baldness at age 45 is linked to a higher risk of certain skin cancers.

research SOX4 Is Essential for Melanoma Tumorigenesis

April 2016 in “Journal of Investigative Dermatology”

SOX4 is crucial for the development of melanoma.

Anti-Androgenetic Alopecia Effect of Policosanol from Chinese Wax by Regulating Abnormal Hormone Levels to Suppress Premature Hair Follicle Entry into the Regression Phase

research Anti-Androgenetic Alopecia Effect of Policosanol from Chinese Wax by Regulating Abnormal Hormone Levels to Suppress Premature Hair Follicle Entry into the Regression Phase

5 citations, January 2021 in “Biomedicine & Pharmacotherapy”

Policosanol helps treat hair loss by balancing hormones and supporting hair growth.

Protective Effect of DA-9401 in Finasteride-Induced Apoptosis in Rat Testis: Inositol Requiring Kinase 1 and c-Jun N-Terminal Kinase Pathway

research Protective Effect of DA-9401 in Finasteride-Induced Apoptosis in Rat Testis: Inositol Requiring Kinase 1 and c-Jun N-Terminal Kinase Pathway

18 citations, October 2017 in “Drug Design Development and Therapy”

DA-9401 helps protect rat testis from finasteride damage.

research Stem Cells and Aberrant Signaling of Molecular Systems in Skin Aging

25 citations, November 2014 in “Ageing Research Reviews”

Skin aging is caused by stem cell damage and can potentially be delayed with treatments like antioxidants and stem cell therapy.

research Male Pattern Baldness and Risk of Incident Skin Cancer in a Cohort of Men

April 2016 in “Journal of Investigative Dermatology”

Male pattern baldness is linked to a higher risk of certain skin cancers, especially on the scalp.

research Skin 3D Bioprinting: Applications in Cosmetology

17 citations, January 2013 in “Journal of Cosmetics, Dermatological Sciences and Applications”

3D bioprinting could improve skin repair and treat conditions like vitiligo and alopecia by precisely placing cells.

research Stem Cell Apoptosis in HIV-1 Alopecia

15 citations, August 2006 in “Journal of Cutaneous Pathology”

HIV-1 may cause increased stem cell death in hair follicles, leading to hair loss.

research Cyclosporine A Increases Hair Follicle Growth by Suppressing Apoptosis-Inducing Factor Nuclear Translocation: A New Mechanism

9 citations, January 2015 in “Fundamental & clinical pharmacology”

Cyclosporine A helps hair grow by blocking a process that would otherwise cause hair cells to die.

research ESGCT and FSGT Collaborative Congress Helsinki, Finland September 17–20, 2015 Abstracts

2 citations, October 2015 in “Human Gene Therapy”

The congress highlighted new gene therapy techniques and cell transplantation methods for treating diseases.

research Oxidative Stress Management in the Hair Follicle: Could Targeting NRF2 Counter Age-Related Hair Disorders and Beyond?

30 citations, July 2017 in “BioEssays”

Activating NRF2 might help treat hair disorders by improving antioxidant defenses.

Symbiotic In Vitro Seed Propagation of Dendrobium: Fungal and Bacterial Partners and Their Influence on Plant Growth and Development

research Symbiotic In Vitro Seed Propagation of Dendrobium: Fungal and Bacterial Partners and Their Influence on Plant Growth and Development

61 citations, May 2015 in “Planta”

Certain fungi and bacteria help orchid seeds germinate and plants grow better.

research Effects of Finasteride on Apoptosis and Regulation of the Human Hair Cycle

23 citations, January 2002 in “Journal of Cutaneous Medicine and Surgery”

Finasteride helps hair growth by decreasing cell death in hair follicles.

research The Anti-Apoptotic Bcl-2 Protein Regulates Hair Follicle Stem Cell Function

10 citations, August 2021 in “EMBO Reports”

The Bcl-2 protein is important for keeping hair follicle stem cells working and preventing hair loss.

A Cell Membrane-Level Approach to Cicatricial Alopecia Management: Is Caveolin-1 a Viable Therapeutic Target in Frontal Fibrosing Alopecia?

research A Cell Membrane-Level Approach to Cicatricial Alopecia Management: Is Caveolin-1 a Viable Therapeutic Target in Frontal Fibrosing Alopecia?

4 citations, May 2021 in “Biomedicines”

Targeting the protein Caveolin-1 might help treat a type of scarring hair loss called Frontal Fibrosing Alopecia.

research Signaling Pathways in Hair Aging

November 2023 in “Frontiers in cell and developmental biology”

Hair aging is caused by stress, hormones, inflammation, and DNA damage affecting hair growth and color.

research From Stem Cells Protection to Skin Microbiota Balance: Orobanche Rapum Extract, a New Natural Strategy

9 citations, November 2018 in “Journal of cosmetic dermatology”

Orobanche rapum extract rejuvenates skin and protects skin bacteria, leading to healthier skin.