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GlossaryCaspase-9

enzyme initiating programmed cell death in response to damage

Caspase-9 is an enzyme that plays a crucial role in the process of apoptosis, which is the programmed cell death essential for maintaining healthy tissue and organ function. It is activated in response to cellular stress or damage and initiates a cascade of events leading to the orderly dismantling of the cell. This enzyme is also known as Apoptotic protease Mch-6 and is vital for preventing the accumulation of damaged or potentially cancerous cells.

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Assessment of the Effect of Ficus Carica Leaf Extract on B16F10 Melanoma Cancer Cells: The Roles of p53, Caspase-3, and Caspase-9 in Inducing Intrinsic Apoptosis Cascade

research Assessment of the Effect of Ficus Carica Leaf Extract on B16F10 Melanoma Cancer Cells: The Roles of p53, Caspase-3, and Caspase-9 in Inducing Intrinsic Apoptosis Cascade

1 citations, October 2021 in “Jundishapur Journal of Natural Pharmaceutical Products”

Ficus carica leaf extract may help treat melanoma by promoting cancer cell death without harming normal cells.

research NLRP1 Promotes Tumor Growth by Enhancing Inflammasome Activation and Suppressing Caspase-3 Activity in Human Melanoma

1 citations, April 2016 in “Journal of Investigative Dermatology”

NLRP1 helps melanoma tumors grow by boosting inflammasome activation and reducing caspase-3 activity.

research Beneficial Effects of Astragaloside IV for Hair Loss via Inhibition of Fas/FasL-Mediated Apoptotic Signaling

29 citations, March 2014 in “PloS one”

Astragaloside IV may help prevent hair loss by blocking a specific pathway that leads to cell death.

research Apoptotic Cells Represent a Dynamic Stem Cell Niche Governing Proliferation and Tissue Regeneration

25 citations, June 2021 in “Developmental Cell”

Dying cells can help with faster healing and new hair growth by releasing a growth-promoting molecule.

research Dexpanthenol Promotes Cell Growth by Preventing Cell Senescence and Apoptosis in Cultured Human Hair Follicle Cells

13 citations, September 2021 in “Current Issues in Molecular Biology”

Dexpanthenol helps human hair follicle cells grow by preventing aging and death, and by supporting growth signals.

research Caspases in Life and Death: Their Role in Head Formation

7 citations, January 2023 in “Frontiers in Cell and Developmental Biology”

Caspases are enzymes important for both cell death and various non-lethal cell functions, affecting head development and hair growth, with different caspases playing specific roles.

research Endocrinology and Metabolism News, August 2005: Effects of Finasteride on Benign Prostatic Hyperplasia Tissues

6 citations, August 2005 in “The Journal of Clinical Endocrinology & Metabolism”

Finasteride causes temporary cell death in BPH tissues.

research Tetrahydroxystilbene Glucoside Effectively Prevents Apoptosis-Induced Hair Loss

9 citations, January 2018 in “BioMed Research International”

Tetrahydroxystilbene Glucoside may help prevent hair loss by blocking certain pathways that lead to cell death.

Forsythiaside A Protects Against Focal Cerebral Ischemic Injury by Mediating the Activation of the Nrf2 and Endoplasmic Reticulum Stress Pathways

research Forsythiaside A Protects Against Focal Cerebral Ischemic Injury by Mediating the Activation of the Nrf2 and Endoplasmic Reticulum Stress Pathways

12 citations, May 2019 in “Molecular Medicine Reports”

Forsythiaside A helps reduce brain damage from lack of blood flow by activating certain protective pathways.

research Protective Effects of BCC Against Oxidative Stress in Cardiomyocyte Cells

March 2024 in “Journal of Experimental & Biomedical Sciences/Biomedical Science Letters”

BCC can protect heart cells from damage caused by oxidative stress.

research Partial Purification and Characterization of Two Distinct Types of Caspases from Human Epidermis

28 citations, September 1998 in “Journal of Investigative Dermatology”

Two distinct caspases in human skin help with cell death and skin formation.

Protective Effect of DA-9401 in Finasteride-Induced Apoptosis in Rat Testis: Inositol Requiring Kinase 1 and c-Jun N-Terminal Kinase Pathway

research Protective Effect of DA-9401 in Finasteride-Induced Apoptosis in Rat Testis: Inositol Requiring Kinase 1 and c-Jun N-Terminal Kinase Pathway

18 citations, October 2017 in “Drug Design Development and Therapy”

DA-9401 helps protect rat testis from finasteride damage.

research Effects of Finasteride on Apoptosis and Regulation of the Human Hair Cycle

21 citations, January 2002 in “Journal of Cutaneous Medicine and Surgery”

Finasteride affects hair growth by changing caspase and XIAP levels, potentially treating hair diseases.

Cedrol Restricts the Growth of Colorectal Cancer In Vitro and In Vivo by Inducing Cell Cycle Arrest and Caspase-Dependent Apoptotic Cell Death

research Cedrol Restricts the Growth of Colorectal Cancer In Vitro and In Vivo by Inducing Cell Cycle Arrest and Caspase-Dependent Apoptotic Cell Death

January 2022 in “International Journal of Medical Sciences”

Cedrol may be an effective treatment for colorectal cancer.

research Uncovering the Role of UV Exposure History and Genetics in Determining Skin Sun Damage

1 citations, April 2016 in “Journal of Investigative Dermatology”

UV photography can help identify people at higher risk for skin cancer, and male pattern baldness at age 45 is linked to a higher risk of certain skin cancers.

research SOX4 Is Essential for Melanoma Tumorigenesis

April 2016 in “Journal of Investigative Dermatology”

SOX4 is crucial for the development of melanoma.

research Stem Cell Apoptosis in HIV-1 Alopecia

15 citations, August 2006 in “Journal of Cutaneous Pathology”

HIV-1 may cause increased stem cell death in hair follicles, leading to hair loss.

12-O-Tetradecanoylphorbol-13-Acetate Induces Apoptosis in Renal Epithelial Cells Through a Growth Signal Conflict Prevented by Activated Ras

research 12-O-Tetradecanoylphorbol-13-Acetate Induces Apoptosis in Renal Epithelial Cells Through a Growth Signal Conflict Prevented by Activated Ras

4 citations, January 2001 in “Archives of Biochemistry and Biophysics”

Activated ras can protect kidney cells from a certain substance that causes cell death.

Symbiotic In Vitro Seed Propagation of Dendrobium: Fungal and Bacterial Partners and Their Influence on Plant Growth and Development

research Symbiotic In Vitro Seed Propagation of Dendrobium: Fungal and Bacterial Partners and Their Influence on Plant Growth and Development

61 citations, May 2015 in “Planta”

Certain fungi and bacteria help orchid seeds germinate and plants grow better.

research Profiling the Response of Human Hair Follicles to Ultraviolet Radiation

53 citations, January 2009 in “Journal of Investigative Dermatology”

UVB radiation harms hair growth and health, causing cell death and other changes in human hair follicles.

research Tumor Cell Adhesion as a Risk Factor for SLN Metastasis and Predictor of Disease Recurrence in Primary Cutaneous Melanoma

April 2016 in “Journal of Investigative Dermatology”

Tumor cell adhesion is linked to higher risk of SLN metastasis and melanoma recurrence, and a model including these factors predicts these outcomes better than one with just clinical data.

research Controlling Hair Loss by Regulating Apoptosis in Hair Follicles: A Comprehensive Overview

1 citations, December 2023 in “Biomolecules”

Regulating cell death in hair follicles can help prevent hair loss and promote hair growth.

research Exosomes Derived Stem Cells as a Modern Therapeutic Approach for Skin Rejuvenation and Hair Regrowth

June 2024 in “Regenerative Therapy”

Exosomes from stem cells may help rejuvenate skin and regrow hair, but more research is needed.

A Cell Membrane-Level Approach to Cicatricial Alopecia Management: Is Caveolin-1 a Viable Therapeutic Target in Frontal Fibrosing Alopecia?

research A Cell Membrane-Level Approach to Cicatricial Alopecia Management: Is Caveolin-1 a Viable Therapeutic Target in Frontal Fibrosing Alopecia?

4 citations, May 2021 in “Biomedicines”

Targeting the protein Caveolin-1 might help treat a type of scarring hair loss called Frontal Fibrosing Alopecia.

research Skin Care Properties of Grape Seed Polyphenols, a By-Product of the Winery Industry

October 2012 in “Humana Press eBooks”

Grape seed extract is good for skin care, with antioxidant, anti-inflammatory, and anti-cancer effects.

research Particulate Matter 2.5 Damages Skin Cells by Inducing Oxidative Stress, Subcellular Organelle Dysfunction, and Apoptosis

215 citations, March 2018 in “Archives of Toxicology”

Tiny pollution particles called PM2.5 can harm skin cells by causing stress, damage to cell parts, and cell death.

research Ultrastructural Evaluation of the Radioprotective Effects of Melatonin Against X-Ray-Induced Skin Damage in Albino Rats

52 citations, January 2005 in “International journal of experimental pathology”

Melatonin may reduce skin damage caused by X-rays in rats.

research Exploring the Drug Repurposing Versatility of Valproic Acid as a Multifunctional Regulator of Innate and Adaptive Immune Cells

47 citations, March 2019 in “Journal of immunology research”

Valproic Acid could potentially be used to treat immune-related conditions due to its ability to modify immune cell functions.

Stress-Sensing in the Human Greying Hair Follicle: Ataxia Telangiectasia Mutated (ATM) Depletion in Hair Bulb Melanocytes in Canities-Prone Scalp

research Stress-Sensing in the Human Greying Hair Follicle: Ataxia Telangiectasia Mutated (ATM) Depletion in Hair Bulb Melanocytes in Canities-Prone Scalp

14 citations, October 2020 in “Scientific reports”

Hair greying is linked to reduced ATM protein in hair cells, which protects against stress and damage.

research Hormonal and Genetic Etiology of Male Androgenetic Alopecia

1 citations, January 2022 in “Springer eBooks”