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GlossaryCaspase-1

enzyme activating inflammatory cytokines and inducing cell death

Caspase-1, also known as Interleukin-1 converting enzyme (ICE), is an enzyme that plays a crucial role in the inflammatory response by activating pro-inflammatory cytokines like interleukin-1β (IL-1β) and interleukin-18 (IL-18). It is also involved in a form of programmed cell death called pyroptosis, which helps the body fight infections by eliminating infected cells.

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research Caspase-1 Level Is Higher in the Scalp in Androgenetic Alopecia

27 citations , July 2012 in “Dermatologic Surgery”

Higher caspase-1 levels found in balding scalps; reducing it may help treat hair loss.

research Distribution of caspase‐14 in epidermis and hair follicles is evolutionarily conserved among mammals

21 citations , September 2005 in “The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology/Anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology”

Caspase-14 is important for skin and hair development in all mammals.

research Expression of apoptosis-related genes in the mouse skin during the first postnatal catagen stage, focused on localization of Bnip3L and caspase-12

4 citations , June 2015 in “Connective tissue research”

The research found changes in gene expression related to cell death in mouse skin that help understand hair follicle development and skin health.

research The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice

59 citations , September 2015 in “Journal of Immunology”

Certain proteins, caspases-1 and -11, are important in the early development of skin inflammation in mice.

research 1117 PX-12 inhibits NLRP3 inflammasome activation to treat psoriasis

May 2023 in “Journal of Investigative Dermatology”

PX-12 may help treat psoriasis by blocking inflammation and cell death.

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community Hair loss causes are still a myth.

in Chat 18 upvotes 2 years ago

The conversation discusses the complexity of hair loss causes, suggesting that DHT sensitivity alone doesn't fully explain it. Treatments mentioned include finasteride and dutasteride.