Higher PDCD4 Expression Is Associated With Obesity, Insulin Resistance, Lipid Metabolism Disorders, And Granulosa Cell Apoptosis In Polycystic Ovary Syndrome

The 2016 study investigated the association of PDCD4 (Programmed Cell Death 4) expression with polycystic ovary syndrome (PCOS) and related metabolic disturbances in 77 PCOS patients and 67 healthy controls. It found that higher PDCD4 expression correlated with obesity, insulin resistance, lipid metabolism disorders, and increased granulosa cell apoptosis in PCOS patients. Metformin treatment significantly reduced PDCD4 expression in obese PCOS women with insulin resistance. The study suggests that PDCD4 may be an independent risk factor for PCOS and could be a potential therapeutic target. However, the exact number of participants involved in the granulosa cell apoptosis analysis was not specified in the summary.