Metabolic Aspects of Different Phenotypes of Polycystic Ovary Syndrome: Iranian PCOS Prevalence Study

    January 2014 in “ Clinical Endocrinology ”
    Farhad Hosseinpanah, Maryam Barzin, Sorena Keihani, Fahimeh Ramezani Tehrani, Fereidoun Azizi
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    TLDR The study suggests that being overweight or obese, not PCOS itself, is strongly linked to insulin resistance.
    The study investigated insulin resistance (IR) and metabolic characteristics in 915 Iranian women, including 136 with polycystic ovary syndrome (PCOS) and 423 healthy controls. It found no significant difference in the prevalence of IR between women with PCOS and normal controls, nor among different PCOS phenotypes after adjusting for age and BMI. Overweight and obesity were identified as having a strong independent association with IR in PCOS subjects. The study suggests that comprehensive metabolic screening may not be necessary for all women with PCOS, particularly those with milder phenotypes, and highlights the need for larger population-based studies to confirm these findings.
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