A Genomic Approach to Susceptibility and Pathogenesis Leads to Identifying Potential Novel Therapeutic Targets in Androgenetic Alopecia

July 2017 in “ Genomics ”

R. Dey-Rao, A. K. Sinha

androgenetic alopecia gene expression scalp biopsies apoptosis cell proliferation WNT signaling transcriptional regulators drug targets AGA

TLDR Genomic approach finds new possible treatments for hair loss.

This document discusses a genomic approach to identifying potential therapeutic targets for androgenetic alopecia (AGA). The study analyzed gene expression patterns in scalp biopsies from individuals with AGA and identified several dysregulated pathways and processes, including apoptosis, cell proliferation, and WNT signaling. The study also identified potential transcriptional regulators and drug targets for future AGA therapies. Overall, this study provides insights into the molecular mechanisms underlying AGA and identifies potential targets for future treatments.

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research Multi-Therapies in Androgenetic Alopecia: Review and Clinical Experiences

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research Hunting the Genes in Male-Pattern Alopecia: How Important Are They, How Close Are We and What Will They Tell Us?

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research Drug Discovery for Alopecia: Gone Today, Hair Tomorrow

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research Does Prostaglandin D2 Hold the Cure to Male Pattern Baldness?

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research Microarray Analysis of Androgenetic and Senescent Alopecia: Comparison of Gene Expression Shows Two Distinct Profiles

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research Androgenetic Alopecia and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis

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research Global Photographic Assessment of Men Aged 18 to 60 Years with Male Pattern Hair Loss Receiving Finasteride 1 mg or Placebo

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research Hair Follicle Stem Cell Differentiation Is Inhibited Through Cross-Talk Between Wnt/β-Catenin and Androgen Signaling in Dermal Papilla Cells From Patients With Androgenetic Alopecia

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research Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia

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research Susceptibility Variants on Chromosome 7p21.1 Suggest HDAC9 as a New Candidate Gene for Male-Pattern Baldness

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research Molecular Basis of Androgenetic Alopecia: From Androgen to Paracrine Mediators Through Dermal Papilla

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research Evaluation of Apoptosis Regulatory Markers in Androgenetic Alopecia

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research Evidence for Two Independent Functional Variants for Androgenetic Alopecia Around the Androgen Receptor Gene

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research Efficacy and Safety of Finasteride Therapy for Androgenetic Alopecia

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research Androgenetic Alopecia and Cardiovascular Risk Factors in Men and Women: A Comparative Study

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research Transcriptional Profiling in Alopecia Areata Defines Immune and Cell Cycle Control Related Genes Within Disease-Specific Signatures

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research Male Androgenetic Alopecia

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research Fine Mapping of the Human AR/EDA2R Locus in Androgenetic Alopecia

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research Androgens and Hair Loss: An In-Depth Analysis of Androgenetic Alopecia

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research Proliferation, DNA Repair, and Apoptosis in Androgenetic Alopecia

19 citations , January 2009 in “Journal of The European Academy of Dermatology and Venereology”

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research The Ludwig Pattern of Androgenetic Alopecia Is Due to a Hierarchy of Androgen Sensitivity Within Follicular Units That Leads to Selective Miniaturization and a Reduction in the Number of Terminal Hairs Per Follicular Unit

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research Male-Pattern Baldness Susceptibility Locus at 20p11

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research EDA2R Is Associated With Androgenetic Alopecia

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research A Multicenter, Randomized, Placebo-Controlled, Double-Blind Clinical Trial of a Novel Formulation of 5% Minoxidil Topical Foam Versus Placebo in the Treatment of Androgenetic Alopecia in Men

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research Scratching the Surface of Skin Development

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research Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells

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research Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia

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research Different Gene Expression Profile Observed in Dermal Papilla Cells Related to Androgenic Alopecia by DNA Macroarray Analysis

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research Identification of Androgen-Inducible TGF-β1 Derived from Dermal Papilla Cells as a Key Mediator in Androgenetic Alopecia

78 citations , June 2003 in “Journal of Investigative Dermatology Symposium Proceedings”

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research Androgens and Alopecia

165 citations , December 2002 in “Molecular and Cellular Endocrinology”

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research A Randomized Clinical Trial of 5% Topical Minoxidil Versus 2% Topical Minoxidil and Placebo in the Treatment of Androgenetic Alopecia in Men

269 citations , September 2002 in “Journal of The American Academy of Dermatology”

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research Androgenetic Alopecia: Analysis of Proliferation and Apoptosis

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research P53 Involvement in the Control of Murine Hair Follicle Regression

71 citations , June 2001 in “American Journal of Pathology”

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research Treatment of Hair Loss

370 citations , September 1999 in “The New England Journal of Medicine”

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research The Biology of Hair Follicles

1113 citations , August 1999 in “The New England Journal of Medicine”

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research WNT Signaling in the Control of Hair Growth and Structure

271 citations , March 1999 in “Developmental biology”

The research shows that a gene called Wnt3 affects hair growth and structure, causing short hair and balding when overactive.

research Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

416 citations , September 1997 in “Journal of Investigative Dermatology”

People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.

research Apoptosis and Cutaneous Biology

60 citations , June 1997 in “Journal of The American Academy of Dermatology”

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