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Glossary Drug Targets

specific molecules drugs interact with to produce therapeutic effects

Drug targets, also known as pharmacological targets or therapeutic targets, are specific molecules in the body, often proteins, that drugs interact with to produce a therapeutic effect. These targets can include enzymes, receptors, ion channels, or other proteins involved in disease processes. By binding to these targets, drugs can modify their activity, leading to changes in cellular function and ultimately improving health outcomes.

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Research

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research Drug Targeting to the Hair Follicles: A Cyclodextrin-Based Drug Delivery

32 citations , March 2009 in “AAPS PharmSciTech”

research Methodologies to Evaluate the Hair Follicle-Targeted Drug Delivery Provided by Nanoparticles

4 citations , July 2023 in “Pharmaceutics (Basel)”

This study reviews various skin models and methodologies used to assess the follicular penetration of nanoparticle-based drugs, highlighting inconsistencies that complicate comparisons and aims to establish more uniform protocols for clearer study outcomes.

research An update on nanocarriers for follicular-targeted drug delivery for androgenetic alopecia topical treatment

January 2025 in “Expert Opinion on Drug Delivery”

This study discusses the limitations of current FDA-approved treatments for androgenic alopecia, noting significant sexual side effects with oral finasteride and formulation challenges with topical minoxidil, and highlights the potential of nanocarriers to improve drug delivery to hair follicles.

research Performance exploration of multi-gene panels of alopecia areata susceptibility and drug-binding targets

1 citations , March 2025 in “Frontiers in Physiology”

This study identified key genes linked to immune cells and potential therapeutic compounds for alopecia areata by evaluating upregulated genes from patient datasets, highlighting T and NK cell involvement in hair follicle attack and suggesting drug candidates through molecular docking and dynamics simulations.

research Hair follicle-targeting drug delivery strategies for the management of hair follicle-associated disorders

14 citations , May 2022 in “Asian Journal of Pharmaceutical Sciences”

This review article highlights how hair follicle-targeting drug delivery systems enhance therapeutic outcomes and reduce side effects for treating conditions like androgenetic alopecia and acne vulgaris. The authors discuss current formulations and evaluate their performance in both preclinical and clinical settings.

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Community Join

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community HMI-115 update: Chime Biologics and Hope Medicine Enter Manufacturing Agreement to Speed up the Launch of First-in-class Antibody Drug HMI-115 Targeting Endometriosis and Androgenic Alopecia

110 upvotes 2 years ago

Chime Biologics and Hope Medicine are speeding up the launch of a first-in-class antibody drug, HMI-115, for endometriosis and androgenic alopecia. The treatment involves a series of subcutaneous injections, has shown promising results in phase 1, and continues to promote hair regrowth even after the treatment is stopped.

community Is there any new drug that looks promising ?

26 upvotes 2 years ago

The conversation discusses GT20029, a drug in Phase II trials that targets androgen receptors with minimal systemic effects, and TDM-105795, a growth stimulant with a different mechanism than minoxidil that may revive papilla stem cells. Both are potential new treatments for hair loss.

community Drug-free hair transplant while waiting for future treatments to become available to public: stupid or good plan?

in Transplants 1 month ago

A user plans a drug-free hair transplant while waiting for future treatments like stem cell therapies, which are projected to be available between 2028 and 2030. Many users express skepticism about the availability of new treatments, suggesting that relying on them is risky and that finasteride remains the most effective option.

community Who is the ideal target for PP405? Will it render hair trasplants obsolete?

2 upvotes 5 months ago

PP405 is being discussed as a potential treatment for hair loss, with uncertainty about its effectiveness compared to existing treatments like finasteride, dutasteride, and minoxidil. There is cautious optimism, but its impact on hair transplants remains unclear.

community Targeted Follicular Finasteride Delivery: A Low-Systemic Strategy

15 upvotes 5 months ago

A peptide-based delivery system for finasteride shows promise in reducing systemic side effects while maintaining hair growth effectiveness. Combining this with other treatments like minoxidil and RU58841 could enhance results with lower systemic absorption.

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