New Drug Targets and Research Methods for Androgenetic Alopecia

February 2009 in “ Folia Pharmacologica Japonica ”

Hisaharu Yamada, Akiko Ikeda

androgenetic alopecia male pattern baldness hair growth cycle in vitro cell culture studies in vivo studies

TLDR The document concludes that more research is needed to create specific drugs for treating male pattern baldness.

This document summarizes a research paper from 2009 that explores the causes and potential treatments for androgenetic alopecia, or male pattern baldness. The paper discusses potential drug targets for treatment development, focusing on molecules involved in the hair growth cycle. It also discusses various methods for evaluating treatment effectiveness, including in vitro cell culture studies and in vivo studies using animals. The authors conclude that further research is needed to develop targeted drugs for the treatment of androgenetic alopecia.

View this study on jstage.jst.go.jp →

Discuss this study in the Community →

Cited in this study

10 / 10 results

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

829 citations , May 2007 in “Nature”

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

research Biology of the Hair Follicle: The Basics

224 citations , March 2006 in “Seminars in Cutaneous Medicine and Surgery”

The document concludes that understanding hair follicle biology can lead to better hair loss treatments.

research Androgen-Inducible TGF-β1 from Balding Dermal Papilla Cells Inhibits Epithelial Cell Growth: A Clue to Understanding Paradoxical Effects of Androgen on Human Hair Growth

190 citations , October 2002 in “The FASEB journal”

Androgens may cause hair loss by increasing TGF-beta1 from scalp cells, which inhibits hair cell growth.

research Hair Growth Effect of Minoxidil

25 citations , March 2002 in “Folia Pharmacologica Japonica”

Minoxidil helps hair grow by improving blood flow and increasing growth factors in hair follicles.

research Towards a Molecular Understanding of Hair Loss and Its Treatment

236 citations , July 2001 in “Trends in Molecular Medicine”

Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.

research Two Distinct Signaling Pathways in Hair Cycle Induction: Stat3-Dependent and Independent Pathways

73 citations , November 2000 in “Proceedings of the National Academy of Sciences of the United States of America”

There are two ways to start hair growth: one needs Stat3 and the other does not, but both need PI3K activation.

research The Effects of Finasteride (Proscar) on Hair Growth, Hair Cycle Stage, and Serum Testosterone and Dihydrotestosterone in Adult Male and Female Stumptail Macaques (Macaca Arctoides)

19 citations , October 1994 in “The Journal of Clinical Endocrinology and Metabolism”

research Hair Growth Effects of Oral Administration of Finasteride, a Steroid 5 Alpha-Reductase Inhibitor, Alone and in Combination with Topical Minoxidil in the Balding Stumptail Macaque

40 citations , February 1992 in “The Journal of Clinical Endocrinology and Metabolism”

Taking finasteride pills and using minoxidil lotion together can help grow hair.

research Action of Topical Minoxidil in the Bald Stump-Tailed Macaque

78 citations , March 1987 in “Journal of The American Academy of Dermatology”

Minoxidil promotes hair growth but stops working when discontinued.

research Growth of the Hair

521 citations , January 1954 in “Physiological Reviews”

Hair growth is cyclic and influenced mainly by local factors.