Hair Growth Effect of DN106212 in C57BL/6 Mouse and Its Network Pharmacological Mechanism of Action

    Ji Yun Baek, Byoung Ha Kim, Dong-Wook Kim, Won-Yung Lee, Chang-Eop Kim, Sujeong Kim, Jae Sung Pyo, Eun-Seok Park, Ki Sung Kang
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    TLDR DN106212, an extract from a plant, is better at promoting hair growth than other tested substances by affecting hair growth factors and follicle development.
    The study investigated the effects of DN106212, an extract of Centipeda minima, on hair growth in C57BL/6 mice. The results showed that DN106212 was more effective in promoting hair growth than both dimethyl sulfoxide (negative control) and tofacitinib (positive control) when applied for 16 days. DN106212 promoted the formation of mature hair follicles and increased the expression of vascular endothelial growth factor (Vegfa) and insulin-like growth factor 1 (Igf1), both related to hair growth. It also inhibited the expression of transforming growth factor beta 1 (Tgfb1), a hair loss-inducing factor. The DN106212 group showed a significantly higher hair growth rate of 51.00% ± 5.28% compared to the tofacitinib group's 49.16% ± 8.52%. The study concluded that DN106212 promotes hair growth by increasing the expression of hair growth factors and promoting the development of hair follicles, suggesting its potential as a therapeutic agent for hair loss. Further studies are needed to investigate the long-term effects and potential side effects of DN106212 on hair growth.
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