Hair Growth Effect of DN106212 in C57BL/6 Mouse and Its Network Pharmacological Mechanism of Action

    Ji Yun Baek, Byoung Ha Kim, Dong-Wook Kim … Ki Sung Kang
    Studysummary In this study, the alcoholic extract DN106212 from Centipeda minima was shown to be more effective in promoting hair growth in C57BL/6 mice compared to dimethyl sulfoxide and tofacitinib, suggesting its potential as a natural hair growth agent.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on mdpi.com →
    Discuss this study in the Community →

    Research cited in this study 31

    1. Dihydrotestosterone Inhibits Hair Growth in Mice by Inhibiting Insulin-Like Growth Factor-I Production in Dermal Papillae Growth Hormone & IGF Research · 2024
    2. The Philippines Stingless Bee Propolis Promotes Hair Growth Through Activation of Wnt/Beta-Catenin Signaling Pathway Jikken Dobutsu · 2022
    3. Hair Growth Stimulation Effect of Centipeda Minima Extract: Identification of Active Compounds and Anagen-Activating Signaling Pathways Biomolecules · 2021
    4. Efficacy of Systemic Minoxidil and Tofacitinib Combination in Treatment-Resistant Alopecia Universalis Journal of Cosmetic Dermatology · 2020
    5. Hair Growth Effect of Emulsion Extracted Brevilin A, a JAK3 Inhibitor, from Centipeda Minima Processes · 2020
    6. Hair-Growth Potential of Ginseng and Its Major Metabolites: A Review on Its Molecular Mechanisms International Journal of Molecular Sciences · 2018
    7. An Open-Label Pilot Study to Evaluate the Efficacy of Tofacitinib in Moderate to Severe Patch-Type Alopecia Areata, Totalis, and Universalis Journal of Investigative Dermatology · 2018
    8. Efficacy of Topical Tofacitinib in Promoting Hair Growth in Non-Scarring Alopecia: Possible Mechanism via VEGF Induction Archives of Dermatological Research · 2017
    9. Study of Gene Expression Alteration in Male Androgenetic Alopecia: Evidence of Predominant Molecular Signaling Pathways British Journal of Dermatology · 2017
    10. Development and Evaluation of Herbal Medicine for Hair Growth-Promoting Activity KSBB Journal · 2016
    11. Mechanism of Action of Herbs and Their Active Constituents Used in Hair Loss Treatment Fitoterapia · 2016
    12. Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth Science Advances · 2015
    13. Collagenase IV Plays an Important Role in Regulating Hair Cycle by Inducing VEGF, IGF-1, and TGF-Beta Expression Drug Design Development and Therapy · 2015
    14. Hair Growth: Focus on Herbal Therapeutic Agents Current Drug Discovery Technologies · 2015
    15. Collagenase IV Plays an Important Role in Regulating Hair Cycle by Inducing VEGF, IGF-1, and TGF-β Expression. PubMed · 2015
    16. Stimulatory Effect of Brazilian Propolis on Hair Growth Through Proliferation of Keratinocytes in Mice Journal of Agricultural and Food Chemistry · 2014
    17. Androgens and Hair: A Biological Paradox with Clinical Consequences Cambridge University Press eBooks · 2012
    18. Effects of Topical Application of EGCG on Testosterone-Induced Hair Loss in a Mouse Model Experimental Dermatology · 2011
    19. Nuclear Factor I-C Regulates TGF-β-dependent Hair Follicle Cycling Journal of Biological Chemistry · 2010
    20. Alopecia Areata Update Journal of The American Academy of Dermatology · 2010
    21. Alopecia Secondary to Mesotherapy Journal of the American Academy of Dermatology · 2009
    22. Female Pattern Hair Loss Springer eBooks · 2008
    23. Positive Lymphocyte Transformation Test in a Patient with Allergic Contact Dermatitis of the Scalp After Short-Term Use of Topical Minoxidil Solution Contact Dermatitis · 2005
    24. The Potential Role of Minoxidil in the Hair Transplantation Setting Dermatologic Surgery · 2002
    25. Telogen Effluvium: Causes, Diagnosis, and Treatment Clinical and Experimental Dermatology · 2002
    26. Female Pattern Hair Loss Clinical and Experimental Dermatology · 2002
    27. Finasteride Drugs · 1999
    28. Clinical and Hormonal Effects of the 5 Alpha-Reductase Inhibitor Finasteride in Idiopathic Hirsutism The Journal of Clinical Endocrinology and Metabolism · 1994
    29. Profile of Alopecia Areata: A Questionnaire Analysis of Patients and Families International Journal of Dermatology · 1992
    30. Biochemical Analysis of Hair Growth from the Aspects of Aging and Enzyme Activities The Journal of Dermatology · 1983
    31. Minoxidil in Resistant Hypertension The Lancet · 1977

    Related research 7

    1. Hair Growth Effect of DN106212 in C57BL/6 Mouse and Its Network Pharmacological Mechanism of Action Current Issues in Molecular Biology · 2023
    2. The Molecular Mechanism of Natural Products Activating Wnt/Beta-Catenin Signaling Pathway for Improving Hair Loss Life · 2022
    3. Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss International Journal of Molecular Sciences · 2020
    4. Hair Physiology: Hair Growth, Alopecia, Scalp Treatment, Etc. Elsevier eBooks · 2017
    5. Activation of Beta-Catenin Signaling in CD133-Positive Dermal Papilla Cells Drives Postnatal Hair Growth PLOS ONE · 2016
    6. Treatment of MSCs with Wnt1a-Conditioned Medium Activates DP Cells and Promotes Hair Follicle Regrowth Scientific Reports · 2014
    7. Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010