Hair Growth Effect of Emulsion Extracted Brevilin A, a JAK3 Inhibitor, from Centipeda Minima

    June 2020 in “ Processes ”
    Byoung Ha Kim, Won-Yung Lee, Tuy An Trinh, Jae Sung Pyo, Sooyeun Lee, Chang-Eop Kim, Dong Hwan Lee, Eun‐Seok Park, Ki Sung Kang
    TLDR CMX from Centipeda minima can significantly improve hair growth in mild to moderate balding.
    The study assessed the hair regrowth effects of CMX, an emulsion extract containing brevilin A from Centipeda minima, a JAK3 inhibitor, in a clinical trial with 72 patients experiencing mild to moderate hair loss. Over 24 weeks, the CMX-treated group showed significant improvements in total, terminal, and anagen hair counts compared to the placebo group, with statistical significance (p < 0.001). The effectiveness of CMX was linked to its modulation of the JAK-STAT signaling pathway and related pathways, suggesting its potential as a promising treatment for hair loss with fewer side effects than traditional drugs.
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