The Use of Janus Kinase Inhibitors in Alopecia Areata: A Review of the Literature

    Erika L Crowley, Shamone C Fine, Kathleen Kwan Katipunan, Melinda Gooderham
    TLDR JAK inhibitors show promise for treating hair loss in alopecia areata but need more clinical trials to confirm safety and effectiveness.
    The review discussed alopecia areata (AA), a chronic immune-mediated disorder causing hair loss, and examined the potential of Janus kinase (JAK) inhibitors as a treatment. Traditional therapies had limited success, but recent studies suggested that JAK inhibitors like baricitinib, ruxolitinib, and tofacitinib could be effective. The review highlighted the role of cytokines interferon-γ and IL-15 in AA's development and linked the condition to the JAK-STAT signaling pathway. Case studies and open-label trials showed promise, and ongoing clinical trials were expected to provide more definitive data on the safety and efficacy of these treatments.
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