Tofacitinib (Selective Janus Kinase Inhibitor 1 and 3): A Promising Therapy for the Treatment of Alopecia Areata: A Case Report of Six Patients

    January 2018 in “ International Journal of Trichology ”
    Chandrashekar Byalekere Shivanna, Chaithra Shenoy, R Arti Priya
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    TLDR Tofacitinib helped regrow hair in patients with alopecia, with few side effects.
    In 2018, a case report studied the effects of Tofacitinib, a selective Janus Kinase inhibitor 1 and 3, on six patients with alopecia areata and alopecia universalis. All patients showed significant hair regrowth after treatment, with effects noticeable by the end of 12 weeks. Four patients continued treatment and were under follow-up, with one not relapsing after stopping the drug for 4 months, and another developing alopecia areata patches in the eyebrows within 2 months of stopping Tofacitinib. Two patients experienced acneiform eruptions, managed with topicals. The report concluded that Tofacitinib effectively treated alopecia without significant adverse side effects, but recommended further controlled studies to confirm its safety and efficacy.
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      Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      in Research  865 upvotes 9 months ago
      The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

      community What else is good. Besides the big 3.

      in Chat  35 upvotes 10 months ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

      community IGE Hair Loss and Miniaturization

      in Chat  3 upvotes 3 months ago
      A 23-year-old male is experiencing diffuse hair loss and miniaturization, possibly due to high IGE levels after using tofacitinib. He seeks advice and has not yet consulted a dermatologist.

      community Topical solution recommendation

      in Treatment  1 upvotes 6 days ago
      The user is using finasteride 1mg every other day and seeks a topical solution excluding minoxidil. They are considering various combinations of ingredients like finasteride, dutasteride, and tofacitinib, with options for nourishing oils and other additives.

      community Topical solution recommendation

      in Product  1 upvotes 6 days ago
      The user is using finasteride 1mg every other day and seeks a topical solution to complement it, excluding minoxidil. They are considering various combinations of ingredients like finasteride, dutasteride, and tofacitinib, with options for nourishing oils and other additives.

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