Efficacy of Tofacitinib in Treatment of Alopecia Universalis in Two Patients

June 2016 in “ Journal of the European Academy of Dermatology and Venereology ”

Aditya K. Gupta, Jessie Carviel, William Abramovits

tofacitinib alopecia universalis hair growth eyebrow regrowth eyelash regrowth scalp hair regrowth beard growth axillary hair regrowth leg hair regrowth Xeljanz

Studysummary In this study, tofacitinib treatment was associated with significant hair regrowth in two patients with alopecia universalis over eight months, with minimal adverse effects reported. Our plain-language summary of this paper — not a Tressless recommendation.

In a 2016 study, two patients with alopecia universalis (AU) were treated with tofacitinib citrate at a dosage of 5 mg twice daily for eight months. The first patient, a 42-year-old male, showed significant beard growth by 3 months, hair growth throughout the body by 6 months, and the development of eyebrows and eyelashes by 8 months. The second patient experienced noticeable scalp hair regrowth after just 1 month, significant scalp regrowth by 4 months, and regrowth of eyelashes, eyebrows, beard, axillary, and isolated leg hair by 8 months. Neither patient reported significant adverse side effects. The study concluded that tofacitinib was effective in treating AU in these patients and suggested further research to confirm its safety and efficacy.

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Research cited in this study

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research Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity

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