Efficacy of Tofacitinib in Treatment of Alopecia Universalis in Two Patients

    June 2016 in “ Journal of the European Academy of Dermatology and Venereology ”
    Aditya K. Gupta, Jessie Carviel, William Abramovits
    Studysummary In this study, tofacitinib treatment was associated with significant hair regrowth in two patients with alopecia universalis over eight months, with minimal adverse effects reported.
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    Research cited in this study 14

    1. The Genetics Of Alopecia Areata: New Approaches, New Findings, New Treatments Journal of Dermatological Science · 2015
    2. Inhibiting Janus Kinases to Treat Alopecia Areata Nature medicine · 2014
    3. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    4. Killing Two Birds with One Stone: Oral Tofacitinib Reverses Alopecia Universalis in a Patient with Plaque Psoriasis Journal of Investigative Dermatology · 2014
    5. Alopecia Areata as a Model for T Cell-Dependent Autoimmune Diseases Experimental Dermatology · 2012
    6. Alopecia Areata: An Autoimmune Disease Causing Hair Loss The New England Journal of Medicine · 2012
    7. Endocannabinoids Limit Excessive Mast Cell Maturation And Activation In Human Skin Journal of Allergy and Clinical Immunology · 2012
    8. Calcitonin Gene-Related Peptide (CGRP) May Award Relative Protection from Interferon-γ-Induced Collapse of Human Hair Follicle Immune Privilege Experimental Dermatology · 2011
    9. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010
    10. Maintenance of Hair Follicle Immune Privilege Is Linked to Prevention of NK Cell Attack Journal of Investigative Dermatology · 2007
    11. Probing the Effects of Stress Mediators on the Human Hair Follicle American Journal of Pathology · 2007
    12. Lymphocytes, Neuropeptides, And Genes Involved In Alopecia Areata Journal of Clinical Investigation · 2007
    13. Immunology of the Human Nail Apparatus: The Nail Matrix Is a Site of Relative Immune Privilege Journal of Investigative Dermatology · 2005
    14. Distribution of Major Histocompatibility Antigens in Normal Skin British Journal of Dermatology · 1983

    Related research 2

    1. Comparison of the Treatment Outcome of Oral Tofacitinib with Other Conventional Therapies in Refractory Alopecia Totalis and Universalis: A Retrospective Study Acta dermato-venereologica · 2018
    2. Alopecia Universalis Unresponsive to Treatment with Tofacitinib: Report of a Case with a Brief Review of the Literature Dermatology online journal · 2017