Inhibiting Janus Kinases to Treat Alopecia Areata

September 2014 in “ Nature medicine ”

Sherrie J. Divito, Thomas S. Kupper

alopecia areata immune-mediated hair loss CD8αβ+NKG2D+ T effector memory cells Janus kinase JAK signaling JAK inhibitors

TLDR JAK inhibitors might help treat alopecia areata.

Alopecia areata, an immune-mediated form of hair loss, was shown to be mediated by CD8αβ+NKG2D+ T effector memory cells through Janus kinase (JAK) signaling. A study using human clinical samples and a mouse model demonstrated that JAK inhibitors could potentially treat this condition.

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