Search
for

    Glossary Janus Kinase

    enzyme involved in cell signaling and immune response

    Janus Kinase (JAK) is a type of enzyme that plays a crucial role in the signaling pathways of cells, particularly in the immune system. It helps transmit signals from various cytokines and growth factors to the cell nucleus, influencing cell growth, survival, development, and differentiation. Dysregulation of JAK activity is associated with various diseases, including certain types of alopecia and autoimmune disorders, making it a target for specific therapeutic drugs known as JAK inhibitors.

    Related Terms

    Research 10 of 1000+

    1. A phase 2a randomized, placebo-controlled study to evaluate the efficacy and safety of the oral Janus kinase inhibitors ritlecitinib and brepocitinib in alopecia areata: 24-week results Journal of the American Academy of Dermatology · 2021 · 138 citations
    2. Targeting the Janus Kinase Family in Autoimmune Skin Diseases Frontiers in Immunology · 2019 · 124 citations
    3. Janus kinase inhibitors in dermatology: A systematic review Journal of the American Academy of Dermatology · 2017 · 116 citations
    4. The emerging role of Janus kinase inhibitors in the treatment of autoimmune and inflammatory diseases 2020 · 70 citations
    5. Efficacy and safety of the oral Janus kinase inhibitor baricitinib in the treatment of adults with alopecia areata: Phase 2 results from a randomized controlled study Journal of The American Academy of Dermatology · 2021 · 66 citations
    6. Janus Kinase Inhibitors for the Treatment of Severe Alopecia Areata: An Open-Label Comparative Study Dermatology · 2018 · 66 citations
    7. Efficacy and safety of deuruxolitinib, an oral selective Janus kinase inhibitor, in adults with alopecia areata: Results from the Phase 3 randomized, controlled trial (THRIVE-AA1) Journal of the American Academy of Dermatology · 2024 · 63 citations
    8. Role of janus kinase inhibitors in the treatment of alopecia areata Drug design, development and therapy · 2018 · 53 citations
    9. Inhibiting Janus kinases to treat alopecia areata Nature medicine · 2014 · 52 citations
    10. Tofacitinib 2% ointment, a topical Janus kinase inhibitor, for the treatment of alopecia areata: A pilot study of 10 patients Journal of the American Academy of Dermatology · 2017 · 48 citations
    All research results →

    Learn 3

    1. Tofacitinib JAK inhibitor pill, an immune-system drug
    2. Baricitinib JAK inhibitor pill used for severe alopecia areata
    3. Alopecia Areata autoimmune disorder causing patchy hair loss

    Community

    — no results

    Try a deeper search in community →