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    Glossary Janus Kinase 3

    enzyme involved in immune cell signaling pathways

    Janus Kinase 3 (JAK3) is an enzyme that plays a crucial role in the signaling pathways of certain types of immune cells. It is involved in the transmission of signals from various cytokine receptors, which are important for the development and function of the immune system. Mutations or malfunctions in JAK3 can lead to immune disorders and have been targeted in treatments for conditions like alopecia areata and rheumatoid arthritis.

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    1. Efficacy and safety of the oral Janus kinase 3/tyrosine kinase expressed in hepatocellular carcinoma family kinase inhibitor ritlecitinib over 24 months: integrated analysis of the ALLEGRO phase IIb/III and long-term phase III clinical studies in alopecia areata British Journal of Dermatology · 2024 · 23 citations
    2. <i>In‐silico</i> Screening of ATP‐competitive Inhibitory Activities of Phytochemicals against Janus Kinase 3 and Its <i>In‐vitro</i> Evaluation ˜The œFASEB journal · 2020
    3. Efficacy and safety of deuruxolitinib, an oral selective Janus kinase inhibitor, in adults with alopecia areata: Results from the Phase 3 randomized, controlled trial (THRIVE-AA1) Journal of the American Academy of Dermatology · 2024 · 63 citations
    4. 170 Forecasting Phase 3 Dose-Response for Abrocitinib, an Oral Janus Kinase 1 Selective Inhibitor, Using Investigator’s Global Assessment and Eczema Area and Severity Index Journal of Investigative Dermatology · 2019
    5. Frontal fibrosing alopecia shows robust T helper 1 and Janus kinase 3 skewing 2020 · 34 citations
    6. Efficacy and safety of deuruxolitinib, an oral selective Janus kinase 1/2 inhibitor, in adults with alopecia areata: Results from the THRIVE-AA2 Phase 3, randomized, double-blind, controlled trial Journal of the American Academy of Dermatology · 2025 · 2 citations
    7. Tofacitinib (Selective Janus Kinase Inhibitor 1 and 3): A promising therapy for the treatment of alopecia areata: A case report of six patients International Journal of Trichology · 2018 · 24 citations
    8. 378 Treatment of severe alopecia areata with the oral Janus kinase inhibitor, tofacitinib: A retrospective chart review Journal of Investigative Dermatology · 2017 · 1 citations
    9. BH09 Patient experience of off-label Janus kinase inhibitor use for alopecia areata in a cohort of 34 patients from a single UK practitioner: exploring changing trends in healthcare provision and access to drug treatments 2023
    10. Treatment of vitiligo with the topical Janus kinase inhibitor ruxolitinib: A 32-week open-label extension study with optional narrow-band ultraviolet B Journal of the American Academy of Dermatology · 2018 · 74 citations
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    1. Tofacitinib JAK inhibitor pill, an immune-system drug
    2. Baricitinib JAK inhibitor pill used for severe alopecia areata
    3. Alopecia Areata autoimmune disorder causing patchy hair loss

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