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GlossaryJanus Kinase 1

enzyme involved in immune signaling and cell growth

Janus Kinase 1 (JAK1) is an enzyme that plays a crucial role in the signaling pathways of various cytokines, which are proteins important for immune system communication. It is part of the JAK family of tyrosine kinases and is involved in processes such as cell growth, development, and immune responses. In the context of hair and alopecia, JAK1 inhibitors are being researched as potential treatments for conditions like alopecia areata, an autoimmune disorder that causes hair loss.

Related Terms

Learn

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learn Tofacitinib

a JAK inhibitor for alopecia areata and other autoimmune conditions

learn Baricitinib

JAK inhibitor that reduces inflammation and immune attacks on hair follicles, leading to potential hair regrowth, especially in alopecia areata cases

learn Alopecia Areata

autoimmune disorder causing patchy hair loss

Research

5 / 1000+ results

Selective Janus Kinase 1 Inhibition Resolves Inflammation and Restores Hair Growth Offering a Viable Treatment Option for Alopecia Areata

research Selective Janus Kinase 1 Inhibition Resolves Inflammation and Restores Hair Growth Offering a Viable Treatment Option for Alopecia Areata

4 citations, January 2023 in “Skin health and disease”

Blocking Janus kinase 1 helps stop inflammation and regrow hair, making it a good treatment for hair loss from alopecia areata.

Forecasting Phase 3 Dose-Response for Abrocitinib, an Oral Janus Kinase 1 Selective Inhibitor, Using Investigator’s Global Assessment and Eczema Area and Severity Index

research Forecasting Phase 3 Dose-Response for Abrocitinib, an Oral Janus Kinase 1 Selective Inhibitor, Using Investigator’s Global Assessment and Eczema Area and Severity Index

September 2019 in “Journal of Investigative Dermatology”

Abrocitinib at 100 mg and 200 mg daily may significantly improve moderate-to-severe atopic dermatitis in patients 12 years and older.

research The Janus Kinase 1 Inhibitor Abrocitinib for the Treatment of Oral Lichen Planus

7 citations, March 2023 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

research Targeting the Janus Kinase Family in Autoimmune Skin Diseases

124 citations, October 2019 in “Frontiers in Immunology”

Janus kinase inhibitors are promising treatments for autoimmune skin diseases like eczema and psoriasis.

research Janus Kinase Inhibitors in Dermatology: A Systematic Review

116 citations, February 2017 in “Journal of the American Academy of Dermatology”

JAK inhibitors help with skin conditions but need more research on dosing and safety.

View more "janus kinase 1" in research →

Community Join

3 / 3 results

community Is it ok to take Xeljanz (A jak inhibitor) while taking finasteride?

in Finasteride 2 upvotes 7 years ago

The conversation is about whether it is safe to take Xeljanz, a JAK inhibitor, while also taking finasteride for hair loss. The concern is that Xeljanz weakens the immune system, which could be risky.

community What else is good. Besides the big 3.

in Chat 34 upvotes 2 months ago

Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

community 8 months apart on the mother of all stacks

in Progress Pictures 149 upvotes 1 year ago

User Tricky9555 tried various hair loss treatments for 8 months with no visible results. Others suggested considering a hair transplant, checking thyroid levels, and being patient for up to 24 months for potential results.