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GlossaryJAK inhibitor

blocks enzymes involved in immune response and inflammation

A JAK inhibitor, also known as a Janus kinase inhibitor or JAKi, is a type of medication that blocks the activity of Janus kinase enzymes. These enzymes play a crucial role in the signaling pathways that regulate immune responses and inflammation. By inhibiting these enzymes, JAK inhibitors can help manage autoimmune diseases and conditions like alopecia areata, where the immune system mistakenly attacks hair follicles.

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research Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib

184 citations , February 2015 in “EBioMedicine”

A patient with Alopecia Areata had complete hair regrowth after using the drug baricitinib.

research STAT5 Activation in the Dermal Papilla Is Important for Hair Follicle Growth Phase Induction

32 citations , April 2016 in “Journal of Investigative Dermatology”

STAT5 activation is crucial for starting the hair growth phase.

research Good Efficacy Achieved by Baricitinib in the Treatment of Anti-MDA5 Antibody-Positive Dermatomyositis with Alopecia Areata

3 citations , February 2022 in “Rheumatology”

Baricitinib was effective in treating a patient with dermatomyositis and hair loss.

research Citrullination at the Inflammatory Skin Barrier

May 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

A potential treatment for atopic dermatitis could be to increase PADI1 expression to improve skin barrier function.

research Application of Baricitinib in Dermatology

14 citations , March 2022 in “Journal of inflammation research”

Baricitinib shows promise as a new treatment for certain skin conditions like alopecia areata.

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