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    Glossary Ritlecitinib

    investigational drug targeting enzymes involved in autoimmune hair loss

    Ritlecitinib is an investigational drug that targets specific enzymes known as Janus kinases (JAKs) and TEC family kinases, which are involved in the immune response. It is being studied for its potential to treat autoimmune conditions like alopecia areata, where the immune system mistakenly attacks hair follicles, leading to hair loss.

    Research 10 of 554

    1. Efficacy and safety of ritlecitinib in adults and adolescents with alopecia areata: a randomised, double-blind, multicentre, phase 2b–3 trial The Lancet · 2023 · 227 citations
    2. A phase 2a randomized, placebo-controlled study to evaluate the efficacy and safety of the oral Janus kinase inhibitors ritlecitinib and brepocitinib in alopecia areata: 24-week results Journal of the American Academy of Dermatology · 2021 · 138 citations
    3. Ritlecitinib: First Approval Drugs · 2023 · 84 citations
    4. Evaluating the Therapeutic Potential of Ritlecitinib for the Treatment of Alopecia Areata Drug Design Development and Therapy · 2022 · 49 citations
    5. Efficacy and safety of ritlecitinib in adolescents with alopecia areata: Results from the ALLEGRO phase 2b/3 randomized, double‐blind, placebo‐controlled trial Pediatric Dermatology · 2023 · 48 citations
    6. Ritlecitinib and brepocitinib demonstrate significant improvement in scalp alopecia areata biomarkers 2021 · 36 citations
    7. Efficacy and safety of the oral Janus kinase 3/tyrosine kinase expressed in hepatocellular carcinoma family kinase inhibitor ritlecitinib over 24 months: integrated analysis of the ALLEGRO phase IIb/III and long-term phase III clinical studies in alopecia areata British Journal of Dermatology · 2024 · 23 citations
    8. Maintenance, withdrawal, and re-treatment with ritlecitinib and brepocitinib in patients with alopecia areata in a single-blind extension of a phase 2a randomized clinical trial Journal of the American Academy of Dermatology · 2021 · 20 citations
    9. Long‐term safety and efficacy of ritlecitinib in adults and adolescents with alopecia areata and at least 25% scalp hair loss: Results from the ALLEGRO‐LT phase 3, open‐label study Journal of the European Academy of Dermatology and Venereology · 2025 · 15 citations
    10. Virtual Bioequivalence Assessment of Ritlecitinib Capsules with Incorporation of Observed Clinical Variability Using a Physiologically Based Pharmacokinetic Model The AAPS Journal · 2024 · 15 citations
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    Community 2

    1. Article of all potential future cures Reddit · 2 May 2025
    2. An arthritis drug that can be used for Alopecia. Reddit · 30 Mar 2022

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