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    Glossary Ritlecitinib

    investigational drug targeting enzymes involved in autoimmune hair loss

    Ritlecitinib is an investigational drug that targets specific enzymes known as Janus kinases (JAKs) and TEC family kinases, which are involved in the immune response. It is being studied for its potential to treat autoimmune conditions like alopecia areata, where the immune system mistakenly attacks hair follicles, leading to hair loss.

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    Research 30 of 554

    1. Efficacy and safety of ritlecitinib in adults and adolescents with alopecia areata: a randomised, double-blind, multicentre, phase 2b–3 trial The Lancet · 2023 · 227 citations
    2. A phase 2a randomized, placebo-controlled study to evaluate the efficacy and safety of the oral Janus kinase inhibitors ritlecitinib and brepocitinib in alopecia areata: 24-week results Journal of the American Academy of Dermatology · 2021 · 138 citations
    3. Ritlecitinib: First Approval Drugs · 2023 · 84 citations
    4. Evaluating the Therapeutic Potential of Ritlecitinib for the Treatment of Alopecia Areata Drug Design Development and Therapy · 2022 · 49 citations
    5. Efficacy and safety of ritlecitinib in adolescents with alopecia areata: Results from the ALLEGRO phase 2b/3 randomized, double‐blind, placebo‐controlled trial Pediatric Dermatology · 2023 · 48 citations
    6. Ritlecitinib and brepocitinib demonstrate significant improvement in scalp alopecia areata biomarkers 2021 · 36 citations
    7. Efficacy and safety of the oral Janus kinase 3/tyrosine kinase expressed in hepatocellular carcinoma family kinase inhibitor ritlecitinib over 24 months: integrated analysis of the ALLEGRO phase IIb/III and long-term phase III clinical studies in alopecia areata British Journal of Dermatology · 2024 · 23 citations
    8. Maintenance, withdrawal, and re-treatment with ritlecitinib and brepocitinib in patients with alopecia areata in a single-blind extension of a phase 2a randomized clinical trial Journal of the American Academy of Dermatology · 2021 · 20 citations
    9. Long‐term safety and efficacy of ritlecitinib in adults and adolescents with alopecia areata and at least 25% scalp hair loss: Results from the ALLEGRO‐LT phase 3, open‐label study Journal of the European Academy of Dermatology and Venereology · 2025 · 15 citations
    10. Virtual Bioequivalence Assessment of Ritlecitinib Capsules with Incorporation of Observed Clinical Variability Using a Physiologically Based Pharmacokinetic Model The AAPS Journal · 2024 · 15 citations
    11. Patterns of clinical response in patients with alopecia areata treated with ritlecitinib in the ALLEGRO clinical development programme Journal of the European Academy of Dermatology and Venereology · 2025 · 13 citations
    12. Sustained hair regrowth with continued ritlecitinib treatment through week 48 in patients with alopecia areata with or without early target responses: Post hoc analysis of the ALLEGRO phase 2b/3 trial Journal of the American Academy of Dermatology · 2024 · 7 citations
    13. Efficacy and safety of ritlecitinib, an oral JAK3/TEC family kinase inhibitor, in adolescent and adult patients with alopecia totalis and alopecia universalis The Journal of Dermatology · 2024 · 7 citations
    14. A Plain Language Summary on Ritlecitinib Treatment for Adults and Adolescents with Alopecia Areata Immunotherapy · 2023 · 7 citations
    15. Long-Term Efficacy of Ritlecitinib up to Month 24 From the ALLEGRO Phase 2b/3 and Long-Term Phase 3 Clinical Studies in Alopecia Areata SKIN The Journal of Cutaneous Medicine · 2024 · 6 citations
    16. Evolution of Ritlecitinib Population Pharmacokinetic Models During Clinical Drug Development Clinical Pharmacokinetics · 2023 · 6 citations
    17. A Phase 1, Open‐Label Study of the Pharmacokinetics of Ritlecitinib in Children Aged 6–12 Years With Alopecia Areata Pediatric Dermatology · 2025 · 5 citations
    18. Efficacy and safety of ritlecitinib in Asian patients with alopecia areata: A subgroup analysis of the ALLEGRO phase 2b/3 trial The Journal of Dermatology · 2025 · 4 citations
    19. Patient-Reported Hair Loss and Its Impacts as Measured by the Alopecia Areata Patient Priority Outcomes Instrument in Patients Treated with Ritlecitinib: The ALLEGRO Phase 2b/3 Randomized Clinical Trial American Journal of Clinical Dermatology · 2024 · 4 citations
    20. A phase 2a study investigating the effects of ritlecitinib on brainstem auditory evoked potentials and intraepidermal nerve fiber histology in adults with alopecia areata Pharmacology Research & Perspectives · 2024 · 4 citations
    21. Integrated Safety Analysis of Ritlecitinib for the Treatment of Alopecia Areata (AA) From the Phase 2 and Phase 3 ALLEGRO Clinical Trial Program SKIN The Journal of Cutaneous Medicine · 2023 · 4 citations
    22. Real-world assessment of ritlecitinib in patients with severe alopecia areata: a 24-week multicentre retrospective study Clinical and Experimental Dermatology · 2025 · 3 citations
    23. Safety and Efficacy of Ritlecitinib for the Treatment of Patients with Alopecia Areata: A Systematic Review and Meta-Analysis of Controlled Trials Journal of Clinical Medicine · 2025 · 3 citations
    24. Impact of Previous Alopecia Areata Treatment on Efficacy Responses up to Week 48 Following Ritlecitinib Treatment: A Post Hoc Analysis Dermatology and Therapy · 2024 · 3 citations
    25. 67 Patterns of clinical response in patients with alopecia areata (AA) treated with ritlecitinib in the ALLEGRO phase 2b/3 and ongoing, phase 3, ALLEGRO-LT studies Journal of Investigative Dermatology · 2023 · 3 citations
    26. SALT score distribution with ritlecitinib treatment up to 24 months in alopecia areata Journal of the European Academy of Dermatology and Venereology · 2025 · 2 citations
    27. Unraveling Ritlecitinib: an in-depth analysis of JAK3 inhibitor for the treatment of alopecia areata Expert Opinion on Drug Metabolism & Toxicology · 2024 · 2 citations
    28. Patient-Reported Satisfaction with Hair Regrowth in a Study of Ritlecitinib in Alopecia Areata: Results from ALLEGRO-2b/3 Dermatology · 2024 · 2 citations
    29. Ritlecitinib for the Management of Alopecia Areata: A Narrative Review of Real-World Evidence and Selected Post Hoc Analyses Dermato · 2026 · 1 citations
    30. Ritlecitinib for Severe Alopecia Areata: A 24-Week, Multicentre, Real-World Study American Journal of Clinical Dermatology · 2026 · 1 citations