The Triumph of JAK Inhibitors for the Treatment of Alopecia Areata

    September 2022 in “ Hair transplant forum international ”
    Sukhmani Pannu, Nathalie Ly, Zehara Abidi, Sophia Fruechte, Ronda S. Farah, Suleima Arruda, Neil S. Sadick, Maria Hordinsky
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    TLDR JAK inhibitors like baricitinib are a new FDA-approved treatment for alopecia areata, but safety data is incomplete.
    Alopecia areata (AA) affects 2% of the U.S. population and is the most common immune-mediated cause of hair loss globally. Historically, there were no FDA-approved treatments for AA, and all treatments were prescribed off-label. The approval of the JAK inhibitor baricitinib by the FDA in June 2022 marks a significant advancement in AA treatment. However, comprehensive safety profile data is still lacking. Ongoing research is exploring topical and sublingual JAK inhibitors, including tofacitinib, ruxolitinib, and ritlecitinib. This review delves into baricitinib's dosing regimen, clinical challenges, and future prospects.
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