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GlossaryRuxolitinib

medication that inhibits JAK enzymes to treat certain diseases

Ruxolitinib, also known by the brand name Jakafi, is a medication that inhibits Janus kinase (JAK) enzymes, which are involved in the signaling pathways that regulate immune function and blood cell production. It is primarily used to treat conditions like myelofibrosis and polycythemia vera, and has shown promise in treating certain types of alopecia by modulating the immune response that attacks hair follicles.

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research Oral Ruxolitinib Induces Hair Regrowth in Patients with Moderate-to-Severe Alopecia Areata

196 citations, September 2016 in “JCI insight”

Ruxolitinib effectively regrows hair in most patients with severe hair loss.

research Rapid Skin Repigmentation on Oral Ruxolitinib in a Patient with Coexistent Vitiligo and Alopecia Areata

157 citations, December 2015 in “Journal of the American Academy of Dermatology”

A man with vitiligo and alopecia saw quick skin and hair improvement with ruxolitinib, but skin color gains were lost after stopping treatment.

research Ruxolitinib for the Treatment of Severe Alopecia Areata

37 citations, September 2018 in “Journal of the American Academy of Dermatology”

Ruxolitinib can help regrow hair in severe alopecia areata.

research Ruxolitinib Protects Skin Stem Cells And Maintains Skin Homeostasis In Murine Graft-Versus-Host Disease

33 citations, January 2018 in “Blood”

Ruxolitinib helps protect skin stem cells and keeps skin healthy in mice with skin GVHD.

research Two Cases of Alopecia Areata Treated with Ruxolitinib: A Discussion of Ideal Dosing and Laboratory Monitoring

25 citations, March 2017 in “International Journal of Dermatology”

Ruxolitinib effectively and safely regrows hair in alopecia patients.

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community Ruxolitinib - Start of a case study

in Research/Science 10 upvotes 7 months ago

The conversation is about a user trying a new hair loss treatment, Ruxolitinib, alongside their existing regimen of finasteride, minoxidil, ketoconazole shampoo, and microneedling. They plan to apply Ruxolitinib to their temples daily for 1-2 months.

community No hair, don't care! [24/F] :)

61 upvotes 8 years ago

A woman with alopecia universalis shares her positive experience of being bald, finding it freeing and less worrisome. She also discusses her skincare routine using Korean products.

community What else is good. Besides the big 3.

in Chat 34 upvotes 2 months ago

Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.