Ruxolitinib Protects Skin Stem Cells And Maintains Skin Homeostasis In Murine Graft-Versus-Host Disease

    January 2018 in “ Blood ”
    Shuichiro Takahashi, Daigo Hashimoto, Eiko Hayase, Reiki Ogasawara, Hiroyuki Ohigashi, Takahide Ara, Emi Yokoyama, Ko Ebata, Satomi Matsuoka, Geoffrey R. Hill, Junichi Sugita, Masahiro Onozawa, Takanori Teshima
    TLDR Ruxolitinib helps protect skin stem cells and keeps skin healthy in mice with skin GVHD.
    The study demonstrated that topical ruxolitinib protected Lgr5+ hair follicle stem cells (HFSCs) and maintained skin homeostasis in murine graft-versus-host disease (GVHD). Unlike corticosteroids, which caused HFSC loss and adverse skin effects, ruxolitinib suppressed donor T cell infiltration and inflammation without damaging skin stem cells. This suggested that ruxolitinib could be a superior treatment for inflammatory skin diseases, including GVHD and alopecia areata, by promoting hair growth and avoiding the complications associated with systemic administration. The findings highlighted a novel mechanism of skin injury in GVHD and proposed a promising therapeutic strategy using JAK inhibitors.
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      in Research/Science  10 upvotes 6 months ago
      The conversation is about a user trying a new hair loss treatment, Ruxolitinib, alongside their existing regimen of finasteride, minoxidil, ketoconazole shampoo, and microneedling. They plan to apply Ruxolitinib to their temples daily for 1-2 months.

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      A woman with alopecia universalis shares her positive experience of being bald, finding it freeing and less worrisome. She also discusses her skincare routine using Korean products.

      community What else is good. Besides the big 3.

      in Chat  36 upvotes 1 month ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

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