Ruxolitinib Protects Skin Stem Cells And Maintains Skin Homeostasis In Murine Graft-Versus-Host Disease

January 2018 in “ Blood ”

Shuichiro Takahashi, Daigo Hashimoto, Eiko Hayase, Reiki Ogasawara, Hiroyuki Ohigashi, Takahide Ara, Emi Yokoyama, Ko Ebata, Satomi Matsuoka, Geoffrey R. Hill, Junichi Sugita, Masahiro Onozawa, Takanori Teshima

ruxolitinib Lgr5+ hair follicle stem cells hair regeneration wound healing corticosteroids topical ruxolitinib skin homeostasis graft-versus-host disease GVHD Jakafi hair stem cells hair growth skin healing steroids topical Jakafi skin balance

Studysummary This study found that topical ruxolitinib protected Lgr5+ skin stem cells and maintained skin homeostasis in skin GVHD, unlike corticosteroids. Our plain-language summary of this paper — not a Tressless recommendation.

The study demonstrated that topical ruxolitinib protected Lgr5+ hair follicle stem cells (HFSCs) and maintained skin homeostasis in murine graft-versus-host disease (GVHD). Unlike corticosteroids, which caused HFSC loss and adverse skin effects, ruxolitinib suppressed donor T cell infiltration and inflammation without damaging skin stem cells. This suggested that ruxolitinib could be a superior treatment for inflammatory skin diseases, including GVHD and alopecia areata, by promoting hair growth and avoiding the complications associated with systemic administration. The findings highlighted a novel mechanism of skin injury in GVHD and proposed a promising therapeutic strategy using JAK inhibitors.

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