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GlossaryRuxolitinib (Jakafi)

medication that inhibits JAK enzymes to treat certain diseases

Ruxolitinib, also known by the brand name Jakafi, is a medication that inhibits Janus kinase (JAK) enzymes, which are involved in the signaling pathways that regulate immune function and blood cell production. It is primarily used to treat conditions like myelofibrosis and polycythemia vera, and has shown promise in treating certain types of alopecia by modulating the immune response that attacks hair follicles.

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research Janus Kinase (JAK) Inhibitors in Treating Alopecia Areata (AA)

September 2014 in “SciBX”

JAK inhibitors may help treat alopecia areata and promote hair regrowth.

research Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth

159 citations, October 2015 in “Science Advances”

Blocking JAK-STAT signaling can lead to hair growth.

research Resident Memory T Cells in Autoimmune Skin Diseases

50 citations, May 2021 in “Frontiers in immunology”

Certain immune cells contribute to skin autoimmune diseases, and some treatments can reverse hair loss in these conditions.

research Novel TMEM173 Mutation and the Role of Disease-Modifying Alleles

47 citations, December 2019 in “Frontiers in immunology”

A new mutation in the STING protein causes a range of symptoms and its severity may be affected by other genetic variations; treatment with a specific inhibitor showed improvement in one patient.

research Janus Kinase (JAK) Inhibitors for the Treatment of Skin and Hair Disorders: A Review of Literature

40 citations, December 2016 in “Journal of Dermatological Treatment”

JAK inhibitors show promise for treating skin and hair disorders but need more research on long-term safety and effectiveness.

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community What else is good. Besides the big 3.

in Chat 34 upvotes 2 months ago

Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.