Hair Follicle-Derived IL-7 and IL-15 Mediate Skin-Resident Memory T Cell Homeostasis and Lymphoma

October 2015 in “ Nature medicine ”

Takeya Adachi, Tetsuro Kobayashi, Eiji Sugihara, Taketo Yamada, Koichi Ikuta, Stefania Pittaluga, Hideyuki Saya, Masayuki Amagai, Keisuke Nagao

IL-7 IL-15 skin-resident memory T cells TRM cutaneous T cell lymphoma CTCL cytokines immune responses inflammatory skin diseases interleukin-7 interleukin-15 skin memory T cells skin lymphoma

TLDR Hair follicle-derived IL-7 and IL-15 are crucial for maintaining skin-resident memory T cells and could be targeted for treating skin diseases and lymphoma.

The study investigated the role of hair follicle-derived interleukins IL-7 and IL-15 in maintaining skin-resident memory T cells (TRM) and their implications in cutaneous T cell lymphoma (CTCL). Using human and mouse models, researchers found that these cytokines were crucial for the survival and homeostasis of TRM cells in the skin. The absence of IL-7 and IL-15 impaired TRM localization and immune responses, and increased IL-7 expression was observed in CTCL patients. The findings suggested that dysregulation of these cytokines could contribute to lymphoma development, highlighting potential therapeutic targets for inflammatory skin diseases and lymphoma.

View this study on europepmc.org →

Discuss this study in the Community →

Research cited in this study

1 / 1 results

research Stress-Induced Production of Chemokines by Hair Follicles Regulates the Trafficking of Dendritic Cells in Skin

286 citations, June 2012 in “Nature Immunology”

Hair follicles help attract immune cells to the skin during stress.

Related Community Posts Join

6 / 74 results

community For Once and For All: Is It the DHT in the Scalp That Matters, Not the DHT in Your Bloodstream?

in Treatment 84 upvotes 3 months ago

DHT in the scalp, not the bloodstream, is crucial for hair loss. Treatments discussed include finasteride, minoxidil, dutasteride, and microneedling.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 667 upvotes 2 months ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community Topical Fin Vs Oral Fin. Which is better and has less sides?

in Finasteride/Dutasteride 45 upvotes 1 year ago

Comparing the effectiveness and side effects of topical finasteride versus oral finasteride, with people sharing their experiences using both treatments to manage hair loss.

community 6 month results on topical min, oral fin, and microneedling

in Progress Pictures 711 upvotes 1 year ago

A user (Majestic-Head3874) who has had successful hair regrowth with the combination of topical minoxidil, oral finasteride and microneedling treatments. People are asking for details about these treatments and Majestic-Head3874 is sharing the regimen they used.

community Before and After, 5 years apart. Topical minoxidil once daily and dutasteride 0,5 mg per day

in Finasteride/Dutasteride 188 upvotes 1 year ago

This conversation is about a user named Pregal1994 discussing their experience with hair loss and treatments of topical minoxidil once daily and dutasteride 0.5 mg per day over 5 years, leading to good results. Other users gave feedback on the photos, confirming that there was an improvement in the condition of the hair.

community ORAL MIN ,DERMAROLLING AND RU58841 PROGRESS 3 months (18,M)

in Progress Pictures 80 upvotes 1 year ago

The conversation is about an 18-year-old's progress with hair regrowth using oral Minoxidil, dermarolling, and RU58841 over three months, starting treatment after beginning to lose hair at 16. Participants are impressed with the improvement and encourage continued treatment.

Related Research

1 / 1 results

research The Effect of Flavonoids on Regenerated Hair Follicles with Pigmentation

April 2017 in “Journal of Dermatological Science”

Certain flavonoids can improve the growth of pigmented hair in mice.