Hair Follicle-Derived IL-7 and IL-15 Mediate Skin-Resident Memory T Cell Homeostasis and Lymphoma

October 2015 in “ Nature medicine ”

Takeya Adachi, Tetsuro Kobayashi, Eiji Sugihara, Taketo Yamada, Koichi Ikuta, Stefania Pittaluga, Hideyuki Saya, Masayuki Amagai, Keisuke Nagao

IL-7 IL-15 skin-resident memory T cells TRM cutaneous T cell lymphoma CTCL cytokines immune responses inflammatory skin diseases interleukin-7 interleukin-15 skin memory T cells skin lymphoma

TLDR Hair follicle-derived IL-7 and IL-15 are crucial for maintaining skin-resident memory T cells and could be targeted for treating skin diseases and lymphoma.

The study investigated the role of hair follicle-derived interleukins IL-7 and IL-15 in maintaining skin-resident memory T cells (TRM) and their implications in cutaneous T cell lymphoma (CTCL). Using human and mouse models, researchers found that these cytokines were crucial for the survival and homeostasis of TRM cells in the skin. The absence of IL-7 and IL-15 impaired TRM localization and immune responses, and increased IL-7 expression was observed in CTCL patients. The findings suggested that dysregulation of these cytokines could contribute to lymphoma development, highlighting potential therapeutic targets for inflammatory skin diseases and lymphoma.

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research Stress-Induced Production of Chemokines by Hair Follicles Regulates the Trafficking of Dendritic Cells in Skin

286 citations, June 2012 in “Nature Immunology”

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