Hair Follicle-Derived IL-7 and IL-15 Mediate Skin-Resident Memory T Cell Homeostasis and Lymphoma
October 2015
in “
Nature medicine
”
Studysummary The research found that hair follicle–derived cytokines, particularly IL-15 and IL-7, regulate skin-resident memory T cells and their role in both immune homeostasis and lymphoma in the skin.
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The study investigated the role of hair follicle-derived interleukins IL-7 and IL-15 in maintaining skin-resident memory T cells (TRM) and their implications in cutaneous T cell lymphoma (CTCL). Using human and mouse models, researchers found that these cytokines were crucial for the survival and homeostasis of TRM cells in the skin. The absence of IL-7 and IL-15 impaired TRM localization and immune responses, and increased IL-7 expression was observed in CTCL patients. The findings suggested that dysregulation of these cytokines could contribute to lymphoma development, highlighting potential therapeutic targets for inflammatory skin diseases and lymphoma.
