Hair Follicle-Derived IL-7 and IL-15 Mediate Skin-Resident Memory T Cell Homeostasis and Lymphoma

The study investigated the role of hair follicle-derived interleukins IL-7 and IL-15 in maintaining skin-resident memory T cells (TRM) and their implications in cutaneous T cell lymphoma (CTCL). Using human and mouse models, researchers found that these cytokines were crucial for the survival and homeostasis of TRM cells in the skin. The absence of IL-7 and IL-15 impaired TRM localization and immune responses, and increased IL-7 expression was observed in CTCL patients. The findings suggested that dysregulation of these cytokines could contribute to lymphoma development, highlighting potential therapeutic targets for inflammatory skin diseases and lymphoma.