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research Hair follicle–derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma

245 citations , October 2015 in “Nature medicine”

The research found that hair follicle–derived cytokines, particularly IL-15 and IL-7, regulate skin-resident memory T cells and their role in both immune homeostasis and lymphoma in the skin.

research Cutting Edge: Memory Regulatory T Cells Require IL-7 and Not IL-2 for Their Maintenance in Peripheral Tissues

140 citations , March 2013 in “The journal of immunology/The Journal of immunology”

This study found that IL-7 is crucial for the survival of memory regulatory T cells in the skin of mice, whereas IL-2 is essential for their initial generation but not for their maintenance.

research Skin-infiltrating CD4+ lymphoma cells depend on hair follicle-derived IL-7

September 2016 in “Journal of Dermatological Science”

This research suggests that hair follicle-derived cytokines IL-7 and IL-15 are crucial for maintaining resident memory T cells in the skin, which may be relevant for diseases like cutaneous T cell lymphoma.

research 700 Tyrosine kinase 2 inhibition rescues hair follicles from IL-12–mediated immune privilege collapse and reverses the induction of human alopecia areata in a humanized mouse model

July 2022 in “Journal of Investigative Dermatology”

This study found that a TYK2 inhibitor, BMS-986202, may restore immune privilege in hair follicles and promote hair regrowth in a humanized alopecia areata mouse model by inhibiting IL-12-mediated signaling.

research 1349 Stimulation of hair follicle stem cell proliferation through an IL-1α dependent activation of γδT-cells

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, IL-1α and IL-7 were found to work together to activate epidermal γδ T-cells, which in turn promote hair follicle stem cell proliferation during mouse wound healing.

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Learn

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learn Hair Transplant

Can everyone have a hair transplant? Not everyone is a candidate; eligibility depends on donor hair availability and overall health.
When can I return to work after a hair transplant? Most patients can return to work within 2 to 7 days after a hair transplant.
Is a hair transplant permanent? Transplanted hair is generally permanent but requires ongoing care to maintain results.
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learn Scalp Micropigmentation

How long does scalp micropigmentation take to heal? Scalp micropigmentation typically takes 7-14 days to heal fully.

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn sh-Polypeptide-7

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Clinics

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Community Join

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community [30M] Regenera Activ (7 Weeks) + Topical Dutasteride/Minoxidil (12 Weeks)

in Progress Pictures 187 upvotes 1 year ago

A 30-year-old man shared his positive experience with hair regrowth using Regenera Activ, topical Dutasteride, Minoxidil, and PRP over 12 weeks. He plans to continue with injectable Dutasteride and emphasizes the importance of starting treatment early to combat hair loss.

community Old study where balding man in his 70s burned his scalp and regrew all his hair

177 upvotes 5 months ago

The conversation discusses unconventional methods for hair regrowth, including scalp trauma like burning or microneedling, and compares them to treatments like Minoxidil and Finasteride. It highlights skepticism about these methods and the body's unpredictable healing responses.

community Fin 1mg / Minoxidil 2.5mg daily

in Is this regrowth? 185 upvotes 1 year ago

The user experienced significant hair regrowth using finasteride 1mg and minoxidil 2.5mg daily over 8-9 months. They reported initial side effects but saw progress around months 7-8, attributing success to patience and consistent use.

community Does 1mg dutasteride get you most of the way there?

in Finasteride/Dutasteride 13 upvotes 1 year ago

1 mg dutasteride may be sufficient for most people, with higher doses showing diminishing returns. Combining dutasteride with minoxidil and ketoconazole can enhance results, but oral minoxidil may cause side effects.

community Progressi in 9 mesi, da luglio 2025 a marzo 2026

in Progress Pictures 153 upvotes 5 months ago

The user shared their 9-month hair regrowth progress using topical Minoxidil 5%, finasteride 0.05%, retinoic acid 0.01%, dermastamping, ketoconazole shampoo, and supplements like biotin. They experienced some hair density improvement but minimal change in the hairline, with initial side effects from finasteride that resolved after dosage adjustment.

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Experts

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