Stress-Induced Production of Chemokines by Hair Follicles Regulates the Trafficking of Dendritic Cells in Skin

    June 2012 in “ Nature Immunology ”
    Keisuke Nagao, Tetsuro Kobayashi, Kazuyo Moro, Manabu Ohyama, Takeya Adachi, Daniela Y. Kitashima, Satoshi Ueha, Keisuke Horiuchi, Hideaki Tanizaki, Kenji Kabashima, Akiharu Kubo, Young-hun Cho, Björn E. Clausen, Kouji Matsushima, Makoto Suematsu, Gláucia C. Furtado, Sérgio A. Lira, Joshua Μ. Farber, Mark C. Udey, Masayuki Amagai
    TLDR Hair follicles help attract immune cells to the skin during stress.
    The study investigated how stress-induced chemokine production by hair follicles regulated dendritic cell (DC) trafficking in the skin. It found that hair follicles produced specific chemokines, such as CCL2, CCL20, and CCL8, which influenced the recruitment and repopulation of Langerhans cells (LCs) and pre-LCs. Hair follicles were essential for LC entry into the epidermis, as pre-LCs did not infiltrate hairless skin. The research highlighted the complex interactions between hair follicles and the immune system, suggesting potential therapeutic targets for conditions like alopecia and other skin diseases.
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