Histopathology of Alopecia: A Clinicopathological Approach to Diagnosis

    December 2009 in “ Histopathology
    Catherine M. Stefanato
    Image of study
    TLDR The conclusion is that accurate diagnosis of different types of hair loss requires good teamwork between skin doctors and lab experts.
    The document reviewed the histopathological diagnosis of scarring and non-scarring alopecias, highlighting the importance of proper tissue sampling, laboratory processing, and clinical information. It detailed the histopathological features of various alopecias, including lymphocytic scarring alopecias like discoid lupus erythematosus and lichen planopilaris, neutrophilic scarring alopecias such as folliculitis decalvans, and non-scarring alopecias like androgenic alopecia, telogen effluvium, and alopecia areata. The document recommended a clinicopathological approach involving both transverse and vertical sectioning of biopsy specimens for improved diagnosis and outlined specific protocols for processing these biopsies. It also described the clinical presentations of these conditions, such as the pattern of hair loss in frontal fibrosing alopecia and central centrifugal cicatricial alopecia, and the histological distinctions between chronic telogen effluvium and female pattern hair loss, as well as the autoimmune nature of alopecia areata. The document emphasized the need for strong communication between dermatologists and pathologists for accurate diagnosis of alopecia.
    Discuss this study in the Community →

    Research cited in this study

    41 / 41 results

    Related Community Posts Join

    6 / 421 results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community The Worst Hair Loss Condition You (MAY) have: LPP

      in Research/Science  43 upvotes 3 months ago
      Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 2 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

      community My scalp punch biopsy results🤔?

      in Female  9 upvotes 1 year ago
      Female using Rogaine foam for hair loss had scalp punch biopsy, diagnosed with Androgenetic Alopecia (AGA). Doctor recommended starting Spironolactone 50mg.

    Related Research

    4 / 4 results